Invitrogen

Jagged1 Polyclonal Antibody

View all (22) Jagged1 antibodies

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Jagged1 Antibody in Western Blot (WB) — Western blot analysis of Jagged1 in PC12 cells (left lane: treated with blocking peptide). Samples were incubated with polyclonal antibody (Product # PA5-115441).

Jagged1 Antibody in Western Blot (WB) — Western blot analysis of Jagged1 in Mouse liver tissue lysates. Samples were incubated with polyclonal antibody (Product # PA5-115441).

Jagged1 Antibody in Western Blot (WB) — Western blot analysis of Jagged1 in 293 whole cells lysates. Samples were incubated with polyclonal antibody (Product # PA5-115441).

Product Details

PA5-115441

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000-1:3,000	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A synthesized peptide derived from human JAG1, corresponding to a region within N-terminal amino acids. View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C
RRID	AB_2900077

Target Information

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD339; jagged canonical Notch ligand 1; Jagged1; Protein jagged-1; Serrate-1

Gene Aliases: ABE2; AGS; AHD; AWS; CD339; Gsfabe2; HJ1; Htu; JAG1; JAGL1; Ozz; Ser-1

UniProt ID: (Human) P78504, (Mouse) Q9QXX0, (Rat) Q63722

Entrez Gene ID: (Human) 182, (Mouse) 16449, (Rat) 29146

angiogenesis cell fate determination blood vessel remodeling morphogenesis of an epithelial sheet T cell mediated immunity pulmonary valve morphogenesis cardiac right ventricle morphogenesis Notch signaling pathway Notch receptor processing nervous system development hemopoiesis keratinocyte differentiation regulation of cell migration response to muramyl dipeptide aorta morphogenesis regulation of cell proliferation auditory receptor cell differentiation myoblast differentiation endothelial cell differentiation negative regulation of fat cell differentiation positive regulation of myeloid cell differentiation negative regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter cardiac septum morphogenesis ciliary body morphogenesis pulmonary artery morphogenesis cardiac neural crest cell development involved in outflow tract morphogenesis Notch signaling involved in heart development endocardial cushion cell development nephron development glomerular visceral epithelial cell development distal tubule development loop of Henle development neuronal stem cell population maintenance negative regulation of stem cell differentiation cell communication multicellular organism development organ morphogenesis camera-type eye development negative regulation of cell differentiation inner ear development organ regeneration

Process(es)

Notch binding structural molecule activity calcium ion binding protein binding growth factor activity