In Western blots, approximately 35% cross-reactivity with recombinant human Jagged 1 is observed and less than 1% cross-reactivity with recombinant rat Jagged 1 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Protein jagged-2 (JAG2) is a Notch signaling pathway protein which is a ligand for Notch-1. It is a single-pass type 1 membrane protein which contains one DSL domain, sixteen EGF-like domains and one VWFC domain. JAG2, along with JAG1, DLL3 and DLL1 act as predominant Notch ligands, which have overlapping receptor binding specificities. JAG2 is also reported to regulating the expression of cytokines that can promote antitumor immunity.
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Protein Aliases: HJ2; Jagged2; Protein jagged-2; SER2
Gene Aliases: HJ2; JAG2; SER2
UniProt ID: (Human) Q9Y219
Entrez Gene ID: (Human) 3714