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Invitrogen

K-Ras (Q61R Mutant) Polyclonal Antibody

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Product Details

PA5-143385

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide surrounding mutant Q61R of human K-Ras. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.54 mg/mL

Amount

54 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.025% Proclin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2938380

Product Specific Information

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

Target Information

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily|A single amino acid substitution is responsible for an activating mutation|The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma|Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-K-RAS; c-Ki-ras2; casein kinase I alpha S-like; Casein kinase I isoform alpha; Casein kinase I isoform alpha-like; CASP-1; caspase 1, apoptosis-related cysteine peptidase; Caspase-1; CFC2; CK1; CKI-alpha; CKI-alpha-like; clock regulator kinase; CSNK1A1; cysteine protease; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; ICE; IL-1 beta-converting enzyme; IL-1BC; IL1B-convertase; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; K-Ras; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS proto-oncogene, GTPase; KRAS1; KRAS2; NS; NS3; p45; RALD; RASK2; unnamed protein product

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Gene Aliases: CASP1; CK1; CK1a; CKIa; CSNK1A1; CSNK1A1L; HEL-S-77p; HLCDGP1; ICE; IL1BC; IL1BCE; P45; PRO2975

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UniProt ID: (Human) P29466, (Human) P48729, (Human) Q8N752

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Entrez Gene ID: (Human) 834, (Human) 1452, (Human) 122011

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Function(s)
endopeptidase activity cysteine-type endopeptidase activity protein binding peptidase activity cysteine-type peptidase activity cysteine-type endopeptidase activator activity involved in apoptotic process hydrolase activity enzyme binding kinase binding cytokine binding identical protein binding CARD domain binding nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding kinase activity transferase activity protein serine kinase activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter plasma membrane repair pattern recognition receptor signaling pathway proteolysis apoptotic process inflammatory response signal transduction osmosensory signaling pathway protein secretion protein autoprocessing protein catabolic process response to lipopolysaccharide positive regulation of interleukin-1 beta production positive regulation of interleukin-18 production interleukin-18-mediated signaling pathway defense response to bacterium regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling icosanoid biosynthetic process ceramide biosynthetic process regulation of inflammatory response positive regulation of inflammatory response protein maturation defense response to virus protein poly-ADP-ribosylation pyroptosis interleukin-1-mediated signaling pathway cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to interferon-gamma cytokine precursor processing signaling receptor ligand precursor processing AIM2 inflammasome complex assembly pyroptotic cell death positive regulation of tumor necrosis factor-mediated signaling pathway autophagosome assembly protein phosphorylation Golgi organization cell surface receptor signaling pathway negative regulation of autophagy positive regulation of autophagy Wnt signaling pathway viral protein processing regulation of Wnt signaling pathway SCF-dependent proteasomal ubiquitin-dependent protein catabolic process cellular response to nutrient levels cellular response to nutrient positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of Rho protein signal transduction TORC1 signaling proteasome-mediated ubiquitin-dependent protein catabolic process NLRP3 inflammasome complex assembly intermediate filament cytoskeleton organization cell division negative regulation of canonical Wnt signaling pathway negative regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly negative regulation of TORC1 signaling positive regulation of TORC1 signaling
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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