Proteintech

KALRN Polyclonal Antibody

View all (6) Kalirin antibodies

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Datasheet

Protocols

Questions & Answers

Tech Support

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KALRN Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 19740-1-AP (KALRN antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

KALRN Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse brain tissue slide using 19740-1-AP ( KALRN Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

KALRN Antibody in Western Blot (WB) — Human kidney tissue were subjected to SDS PAGE followed by western blot with 19740-1-AP (KALRN antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

Product Details

19740-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-
Immunocytochemistry (ICC/IF)	1:50-1:500	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Peptide
Conjugate	Unconjugated
Form	Liquid
Concentration	0.13 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

The antibody can recognize isoform1 and isoform2 of KALRN.

Target Information

HAP1 (huntingtin-associated protein 1) binds to huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of huntingtin that leads to Huntington's disease (HD). The ability of HAP1 to bind to huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons. Duo, also designated huntingtin-associated protein interacting protein or HAPIP, binds Huntingtin-associated protein 1 (HAP1) and may have a role in vesicle trafficking and cytoskeletal function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ12332; FLJ16443; FLJ18196; FLJ18623; hCG_2022551; huntingtin-associated protein interacting protein (duo); Huntingtin-associated protein-interacting protein; Kalirin; kalrn; Protein Duo; RhoGEF kinase; serine/threonine kinase with Dbl- and pleckstrin homology domain; serine/threonine kinase with Dbl- and pleckstrin homology domains; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain

Gene Aliases: 2210407G14Rik; ARHGEF24; AV235988; CHD5; CHDS5; DUET; DUO; E530005C20Rik; Gm539; HAPIP; KALRN; TRAD

UniProt ID: (Human) O60229, (Mouse) A2CG49

Entrez Gene ID: (Human) 8997, (Mouse) 545156

Molecular Function: guanyl-nucleotide exchange factor non-receptor serine/threonine protein kinase