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Proteintech
KANK2 Polyclonal Antibody
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Product Details
20546-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.49 mg/mL
Amount
73.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to KANK2.
Target Information
This gene encodes a member of the KN motif and ankyrin repeat domains (KANK) family of proteins, which play a role in cytoskeletal formation by regulating actin polymerization. The encoded protein functions in the sequestration of steroid receptor coactivators and possibly other proteins. Mutations in this gene are associated with impaired kidney podocyte function and nephrotic syndrome, and keratoderma and woolly hair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANKRD25; ankyrin repeat domain 25; Ankyrin repeat domain-containing protein 25; kidney ankyrin repeat-containing protein 2; KN motif and ankyrin repeat domain-containing protein 2; Matrix-remodeling-associated protein 3; SIP; SRC-1-interacting protein; SRC-interacting protein; SRC1-interacting protein; steroid receptor coactivator interacting protein; unnamed protein product
Gene Aliases: AI504612; ANKRD25; BC010245; KANK2; KIAA1518; MXRA3; NPHS16; PPKWH; RGD1563532; SIP
UniProt ID: (Human) Q63ZY3, (Rat) D3ZD05, (Mouse) Q8BX02
Entrez Gene ID: (Human) 25959, (Rat) 100361376, (Mouse) 235041
negative regulation of transcription from RNA polymerase II promoter
apoptotic process
negative regulation of cell proliferation
negative regulation of actin filament polymerization
negative regulation of intracellular estrogen receptor signaling pathway
regulation of Rho protein signal transduction
negative regulation of programmed cell death
negative regulation of vitamin D receptor signaling pathway
kidney epithelium development
glomerular visceral epithelial cell migration
negative regulation of G1/S transition of mitotic cell cycle
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of stress fiber assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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