A suggested positive control is mouse brain tissue lysate.
PA5-34539 can be used with blocking peptide PEP-1582.
Ankyrins are membrane adaptor molecules that play important roles in the control of cytoskeleton formation by regulating actin polymerization. KANK2 (KN motif and ankyrin repeat domain-containing protein 2), was initially identified as a steroid receptor coactivator (SRC) interacting protein (SIP) that could sequester steroid receptor coactivators in the cytoplasm. More recent experiments have shown that while KANK2 is widely expressed, in kidney podocytes, KANK2 localizes to foot processes, suggesting that KANK2 may contribute to controlling actin dynamics in podocyte foot processes.
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Protein Aliases: ANKRD25; ankyrin repeat domain 25; Ankyrin repeat domain-containing protein 25; KANK2; kidney ankyrin repeat-containing protein 2; KN motif and ankyrin repeat domain-containing protein 2; KN motif and ankyrin repeat domains 2; Matrix-remodeling-associated protein 3; MXRA3; SIP; SRC-1-interacting protein; SRC-interacting protein; SRC1-interacting protein
Gene Aliases: AI504612; ANKRD25; BC010245; KANK2; KIAA1518; MXRA3; PPKWH; RGD1563532; SIP