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Invitrogen
KAP3 Polyclonal Antibody
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FIGURE: 1 / 2
KAP3 Antibody (PA5-67943) in ICC/IF
Immunocytochemical analysis of KAP3 in formalin-fixed H9C2 cells. Cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with KAP3 Polyclonal Antibody (Product # PA5-67943) in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a AF594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Product Details
PA5-67943
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human KAP3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.87% NaCl, 30% glycerol
Contains
0.01% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KAP-3; Kinesin-associated protein 3; small G protein GDP dissociation stimulator; Smg GDS-associated protein
Gene Aliases: dJ190I16.1; FLA3; KAP-1; KAP-3; KAP3; KIF3AP; KIFAP3; SMAP; Smg-GDS
UniProt ID: (Human) Q92845, (Mouse) P70188
Entrez Gene ID: (Human) 22920, (Rat) 289168, (Mouse) 16579
protein complex assembly
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based process
microtubule-based movement
signal transduction
protein localization
negative regulation of cell proliferation
antigen processing and presentation of exogenous peptide antigen via MHC class II
negative regulation of apoptotic process
positive regulation of calcium-dependent cell-cell adhesion
plus-end-directed vesicle transport along microtubule
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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