Proteintech

KATNA1 Polyclonal Antibody

FIGURE: 1 / 4

KATNA1 Antibody (17560-1-AP) in WB

Mouse brain tissue were subjected to SDS PAGE followed by western blot with 17560-1-AP (KATNA1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

KATNA1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17560-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunocytochemistry (ICC/IF)

Assay-dependent

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KATNA1 Fusion Protein Ag11753 (1-311 aa encoded by BC050428)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSLLMISEN VKLAREYALL GNYDSAMVYY QGVLDQMNKY LYSVKDTYLQ QKWQQVWQEI NVEAKHVKDI MKTLESFKLD STPLKAAQHD LPASEGEVWS MPVPVERRPS PGPRKRQSSQ YSDPKSHGNR PSTTVRVHRS SAQNVHNDRG KAVRCREKKE QNKGREEKGV LMVGPPGTGK TLLAKAVATE CKTTFFNVSS STLTSKYRGE SEKLVRLLFE MARFYSPATI FIDEIDSICS RRGTSEEHEA SRRVKAELLV QMDGVGGTSE NDDPSKMVMV LAATNFPWDI DEALRRRLEK RIYIPLPSGM RP (1-311 aa encoded by BC050428)

Target Information

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth.

The Journal of biological chemistry

Li S,Liang Y,Zou J,Cai Z,Yang H,Yang J,Zhang Y,Lin H,Zhang G,Tan M

Thu Sep 01 00:00:00 UTC 2022

SUMOylation of microtubule-cleaving enzyme KATNA1 promotes microtubule severing and neurite outgrowth.

The Journal of biological chemistry

Li S,Liang Y,Zou J,Cai Z,Yang H,Yang J,Zhang Y,Lin H,Zhang G,Tan M

Thu Sep 01 00:00:00 UTC 2022

Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.

Cell research

Wang L,Paudyal SC,Kang Y,Owa M,Liang FX,Spektor A,Knaut H,Sánchez I,Dynlacht BD

Tue Feb 01 00:00:00 UTC 2022

Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission.

eLife

Wenzel DM,Mackay DR,Skalicky JJ,Paine EL,Miller MS,Ullman KS,Sundquist WI

Thu Sep 15 00:00:00 UTC 2022

Transthyretin Promotes Axon Growth via Regulation of Microtubule Dynamics and Tubulin Acetylation.

Frontiers in cell and developmental biology

Eira J,Magalhães J,Macedo N,Pero ME,Misgeld T,Sousa MM,Bartolini F,Liz MA

Tue Nov 30 00:00:00 UTC 2021

RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin.

Cells

Tan D,Zhang H,Deng J,Liu J,Wen J,Li L,Wang X,Pan M,Hu X,Guo J

Thu Jan 16 00:00:00 UTC 2020

RhoA-GTPase Modulates Neurite Outgrowth by Regulating the Expression of Spastin and p60-Katanin.

Cells

Tan D,Zhang H,Deng J,Liu J,Wen J,Li L,Wang X,Pan M,Hu X,Guo J

Thu Jan 16 00:00:00 UTC 2020

Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.

European journal of medicinal chemistry

Gao F,Liang Y,Zhou P,Cheng J,Ding K,Wang Y

Sun Sep 15 00:00:00 UTC 2019

Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.

PLoS biology

Mirvis M,Siemers KA,Nelson WJ,Stearns TP

Mon Jul 01 00:00:00 UTC 2019

Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.

Structure (London, England : 1993)

Jiang K,Faltova L,Hua S,Capitani G,Prota AE,Landgraf C,Volkmer R,Kammerer RA,Steinmetz MO,Akhmanova A

Tue Mar 06 00:00:00 UTC 2018

Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.

Structure (London, England : 1993)

Jiang K,Faltova L,Hua S,Capitani G,Prota AE,Landgraf C,Volkmer R,Kammerer RA,Steinmetz MO,Akhmanova A

Tue Mar 06 00:00:00 UTC 2018

Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.

Nature cell biology

Jiang K,Rezabkova L,Hua S,Liu Q,Capitani G,Altelaar AFM,Heck AJR,Kammerer RA,Steinmetz MO,Akhmanova A

Mon May 01 00:00:00 UTC 2017

Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.

Nature cell biology

Jiang K,Rezabkova L,Hua S,Liu Q,Capitani G,Altelaar AFM,Heck AJR,Kammerer RA,Steinmetz MO,Akhmanova A

Mon May 01 00:00:00 UTC 2017

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Hu WF,Pomp O,Ben-Omran T,Kodani A,Henke K,Mochida GH,Yu TW,Woodworth MB,Bonnard C,Raj GS,Tan TT,Hamamy H,Masri A,Shboul M,Al Saffar M,Partlow JN,Al-Dosari M,Alazami A,Alowain M,Alkuraya FS,Reiter JF,Harris MP,Reversade B,Walsh CA

Wed Dec 17 00:00:00 UTC 2014

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Wed Dec 17 00:00:00 UTC 2014

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Wed Dec 17 00:00:00 UTC 2014

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Wed Dec 17 00:00:00 UTC 2014

Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.

Developmental cell

Jiang K,Hua S,Mohan R,Grigoriev I,Yau KW,Liu Q,Katrukha EA,Altelaar AF,Heck AJ,Hoogenraad CC,Akhmanova A

Mon Feb 10 00:00:00 UTC 2014

Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.

Developmental cell

Jiang K,Hua S,Mohan R,Grigoriev I,Yau KW,Liu Q,Katrukha EA,Altelaar AF,Heck AJ,Hoogenraad CC,Akhmanova A

Mon Feb 10 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: katanin p60 (ATPase containing) subunit A 1; katanin p60 (ATPase-containing) subunit A 1; Katanin p60 ATPase-containing subunit A1; katanin p60 ATPase-containing subunit A1 {ECO:0000255|HAMAP-Rule:MF_03023}; katanin p60 subunit A 1; Katanin p60 subunit A1; katanin p60 subunit A1 {ECO:0000255|HAMAP-Rule:MF_03023}; KATNA1; lipotransin; microtubule severing protein; p60 katanin; p60 katanin {ECO:0000255|HAMAP-Rule:MF_03023}

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Gene Aliases: KATNA1

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UniProt ID: (Human) O75449, (Rat) Q6E0V2

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Entrez Gene ID: (Human) 11104, (Rat) 292464, (Mouse) 23924

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Function(s)

protein binding ATP binding microtubule binding microtubule-severing ATPase activity protein heterodimerization activity ubiquitin-protein transferase activity ATPase activity dynein binding nucleotide binding hydrolase activity non-motor microtubule binding protein

Process(es)

mitotic nuclear division negative regulation of neuron projection development cytoplasmic microtubule organization microtubule severing cell division microtubule bundle formation neuron migration protein localization metabolic process protein ubiquitination cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KATNA1 Polyclonal Antibody

KATNA1 Antibody (17560-1-AP) in WB

Product Details

17560-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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