Proteintech

KATNB1 Polyclonal Antibody

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KATNB1 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 14969-1-AP (KATNB1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

KATNB1 Antibody in Western Blot (WB) — Mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 14969-1-AP (KATNB1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

KATNB1 Antibody in Immunoprecipitation (IP) — IP result of anti-KATNB1 (IP:14969-1-AP, 3ug; Detection:14969-1-AP 1:500) with HeLa cells lysate 3000ug.

Product Details

14969-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 3 publications 3 publications
Immunocytochemistry (ICC/IF)	1:50-1:500	View 2 publications 2 publications
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	KATNB1 Fusion Protein Ag6836 (305-655 aa encoded by BC001353) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.21 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: VTRTGTVAR DPVQDHRPLA QPLPNPSAPL RRIYERPSTT CSKPQRVKQN SESERRSPSS EDDRDERESR AEIQNAEDYN EIFQPKNSIS RTPPRRSEPF PAPPEDDAAT AKEAAKPSPA MDVQFPVPNL EVLPRPPVVA STPAPKAEPA IIPATRNEPI GLKASDFLPA VKIPQQAELV DEDAMSQIRK GHDTMCVVLT SRHKNLDTVR AVWTMGDIKT SVDSAVAIND LSVVVDLLNI VNQKASLWKL DLCTTVLPQI EKLLQSKYES YVQTGCTSLK LILQRFLPLI TDMLAAPPSV GVDISREERL HKCRLCYKQL KSISGLVKSK SGLSGRHGST FRELHLLMAS LD (305-655 aa encoded by BC001353)

Target Information

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Klebsiella pneumoniae disassembles host microtubules in lung epithelial cells.

Cellular microbiology

Chua MD,Liou CH,Bogdan AC,Law HT,Yeh KM,Lin JC,Siu LK,Guttman JA

Fri Mar 01 00:00:00 EST 2019

Structural Basis of Formation of the Microtubule Minus-End-Regulating CAMSAP-Katanin Complex.

Structure (London, England : 1993)

Jiang K,Faltova L,Hua S,Capitani G,Prota AE,Landgraf C,Volkmer R,Kammerer RA,Steinmetz MO,Akhmanova A

Tue Mar 06 00:00:00 EST 2018

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Hu WF,Pomp O,Ben-Omran T,Kodani A,Henke K,Mochida GH,Yu TW,Woodworth MB,Bonnard C,Raj GS,Tan TT,Hamamy H,Masri A,Shboul M,Al Saffar M,Partlow JN,Al-Dosari M,Alazami A,Alowain M,Alkuraya FS,Reiter JF,Harris MP,Reversade B,Walsh CA

Wed Dec 17 00:00:00 EST 2014

Katanin p80 regulates human cortical development by limiting centriole and cilia number.

Neuron

Wed Dec 17 00:00:00 EST 2014

Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.

Developmental cell

Jiang K,Hua S,Mohan R,Grigoriev I,Yau KW,Liu Q,Katrukha EA,Altelaar AF,Heck AJ,Hoogenraad CC,Akhmanova A

Mon Feb 10 00:00:00 EST 2014

Bioinformatics

Protein Aliases: katanin (80 kDa); katanin p80 (WD repeat containing) subunit B 1; katanin p80 (WD40-containing) subunit B 1; Katanin p80 subunit B1; Katanin p80 WD40 repeat-containing subunit B1; katanin p80 WD40-containing subunit B1; KATNB1; p80 katanin

Gene Aliases: 2410003J24Rik; KAT; KATNB1; LIS6

UniProt ID: (Human) Q9BVA0, (Mouse) Q8BG40

Entrez Gene ID: (Human) 10300, (Mouse) 74187, (Rat) 291852

Function(s)