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Invitrogen
KCC3 Polyclonal Antibody
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Product Details
PA5-50526
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human Solute carrier family 12 (potassium/chloride transporters), member 6
Conjugate
Form
Liquid
Concentration
1.2 mg/mL
Amount
120 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total KCC3 / SLC12A6 protein.
Target Information
SLC12A6 is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZP434D2135; Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3; KCC3; KCC3a exon 1a splice variant; KCC3a exon 1a splice variant 2; KCC3a exon 2 splice variant; potassium chloride cotransporter 3; potassium chloride cotransporter KCC3a-S3; potassium-chloride transporter-3a; potassium-chloride transporter-3b; SLC121A6; solute carrier family 12 (potassium/chloride transporter), member 6; solute carrier family 12 (potassium/chloride transporters), member 6; Solute carrier family 12 member 6; unnamed protein product
Gene Aliases: ACCPN; CMT2II; KCC3; KCC3A; KCC3B; SLC12A6
UniProt ID: (Human) Q9UHW9
Entrez Gene ID: (Human) 9990
angiogenesis
ion transport
potassium ion transport
cell volume homeostasis
chemical synaptic transmission
chloride ion homeostasis
potassium ion homeostasis
transmembrane transport
cellular response to glucose stimulus
cellular hypotonic response
cellular hypotonic salinity response
potassium ion transmembrane transport
chloride transmembrane transport
potassium ion import across plasma membrane
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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