Immunogen sequence: MYPESTTGS PARLSLRQTG SPGMIYSTRY GSPKRQLQFY RNLGKSGLRV SCLGLGTWVT FGGQITDEMA EQLMTLAYDN GINLFDTAEV YAAGKAEVVL GNIIKKKGWR RSSLVITTKI FWGGKAETER GLSRKHIIEG LKASLERLQL EYVDVVFANR PDPNTPMEET VRAMTHVINQ GMAMYWGTSR WSSMEIMEAY SVARQFNLTP PICEQAEYHM FQREKVEVQL PELFHKIGVG AMTWSPLACG IVSGKYDSGI PPYSRASLKG YQWLKDKILS EEGRRQQAKL KELQAIAERL GCTLPQLAIA WCLRNEGVSS VLLGASNADQ LMENIGAIQV RVRGPAGQRA HPSPSPVQCI LPGSSCVPGS VLGTQDAPVN HQSCAPGELA FQQEQT (1-395 aa encoded by B C110351)
Kcnab2 is a voltage-gated potassium channels (KV) belong to the 6-TM family of potassium channel that also comprises the Ca2+-activated Slo (actually 7-TM) and the Ca2+-activated SK subfamilies. The alpha-subunits contain a single pore-forming region and combine to form tetramers. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of potassium channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). Kcnab2 is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. Alternative splicing of the Kcnab2 gene results in multiple transcript variants encoding distinct isoforms. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome.
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Protein Aliases: hKvbeta2; K(+) channel subunit beta-2; Kv-beta-2; Kvbeta2; Neuroimmune protein F5; potassium channel, voltage gated shaker-related subfamily A regulatory beta subunit 2; potassium channel, voltage gated subfamily A regulatory beta subunit 2; potassium voltage gated channel, shaker related subfamily, beta member 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; Voltage-gated potassium channel subunit beta-2
Gene Aliases: AKR6A5; Ckbeta2; F5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; I2rf5; KCNA2B; KCNAB2; Kcnb3; KCNK2; KV-BETA-2