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KCNE1 Polyclonal Antibody
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Product Details
BS-9928R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human KCNE1, amino acids 64-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Kcne1 is a member of Voltage-gated potassium (Kv) channels that represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. The diverse functions of Kv channels include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. The Kcne1 gene encodes a membrane protein which has sequence similarity to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. Kcne1, an intronless gene is deleted in AMME contiguous gene syndrome and may be involved in the cardiac and neurologic abnormalities found in the AMME contiguous gene syndrome. Functionally, Kcne1 is a potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Kcne1 also functions as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1. Diseases associated with KCNE1 include Jervell And Lange-Nielsen Syndrome 2 and Long Qt Syndrome 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiac delayed rectifier potassium channel protein; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; JLNS 2; KCNE 1; KCNE1; KCNE1 (IsK); Long QT syndrome 5; LQT 5; MGC33114; Minimal potassium channel; MinK; mISK; potassium (K+) channel protein, slowly activating (Isk); potassium channel, voltage gated subfamily E regulatory beta subunit 1; potassium voltage-gated channel Shaw-related subfamily member 1; Potassium voltage-gated channel subfamily E member 1; potassium voltage-gated channel subfamily E member 1-like; potassium voltage-gated channel, Isk-related family, member 1; potassium voltage-gated channel, Isk-related subfamily, member 1; unnamed protein product; voltage gated potassiun channel accessory subunit
Gene Aliases: ISK; JLNS; JLNS2; KCNE1; LQT2/5; LQT5; m; MinK; nmf190
UniProt ID: (Human) P15382, (Mouse) P23299, (Rat) P15383
Entrez Gene ID: (Dog) 487743, (Human) 3753, (Mouse) 16509, (Rat) 25471
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
potassium channel activity
protein binding
potassium channel regulator activity
telethonin binding
ion channel binding
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
voltage-gated ion channel activity
protein heterodimerization activity
voltage-gated ion channel
epithelial cell maturation
ion transport
potassium ion transport
sensory perception of sound
vestibular nucleus development
secretory granule organization
ion transmembrane transport
regulation of membrane potential
regulation of potassium ion transport
heart contraction
regulation of ventricular cardiac muscle cell membrane repolarization
cellular response to cAMP
potassium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
ventricular cardiac muscle cell action potential
membrane repolarization
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
negative regulation of protein targeting to membrane
potassium ion export across plasma membrane
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
negative regulation of delayed rectifier potassium channel activity
transport
regulation of ion transmembrane transport
regulation of membrane repolarization
cellular response to acidic pH
positive regulation of voltage-gated calcium channel activity
negative regulation of voltage-gated potassium channel activity
protein N-linked glycosylation
protein O-linked glycosylation
male gonad development
potassium ion export
regulation of delayed rectifier potassium channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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