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KCNE2 Antibody (PA5-118799) in IHC (P)
Immunohistochemical analysis of KCNE2 in Mouse stomach tissue using a KCNE2 polyclonal antibody (Product # PA5-118799). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the secondary antibody.
Product Details
PA5-118799
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KCNE2(Accession Q9Y6J6), corresponding to amino acid residues Y52-N102.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2903299
Product Specific Information
Antibody detects endogenous levels of total KCNE2.
Target Information
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cardiac voltage-gated potassium channel accessory subunit 2; CDW210B; CRFB4; D21S58; D21S66; IL-10R2; minimum potassium ion channel related peptide 1; Minimum potassium ion channel-related peptide 1; MinK-related peptide 1; minK-related peptide-1; Potassium channel subunit beta MiRP1; potassium channel subunit, MiRP1; potassium channel, voltage gated subfamily E regulatory beta subunit 2; Potassium voltage-gated channel subfamily E member 2; potassium voltage-gated channel, Isk-related family, member 2; potassium voltage-gated channel, Isk-related subfamily, gene 2; voltage-gated K+ channel subunit MIRP1
Gene Aliases: 2200002I16Rik; ATFB4; AW048273; KCNE2; LQT5; LQT6; MIRP1
UniProt ID: (Human) Q9Y6J6, (Rat) P63161, (Mouse) Q9D808
Entrez Gene ID: (Human) 9992, (Rat) 171138, (Mouse) 246133
inward rectifier potassium channel activity
delayed rectifier potassium channel activity
protein binding
potassium channel regulator activity
protein homodimerization activity
ion channel binding
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity
cation channel activity
voltage-gated ion channel activity
potassium channel activity
voltage-gated ion channel
aging
potassium ion import
cellular response to drug
tongue development
regulation of membrane repolarization
regulation of ventricular cardiac muscle cell membrane repolarization
cardiac conduction
potassium ion export
potassium ion transmembrane transport
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
membrane repolarization
membrane repolarization during action potential
regulation of heart rate by cardiac conduction
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of potassium ion transmembrane transport
positive regulation of voltage-gated calcium channel activity
positive regulation of proteasomal protein catabolic process
regulation of inward rectifier potassium channel activity
regulation of cyclic nucleotide-gated ion channel activity
regulation of delayed rectifier potassium channel activity
negative regulation of delayed rectifier potassium channel activity
cellular protein localization
negative regulation of voltage-gated potassium channel activity
transport
ion transport
potassium ion transport
regulation of ion transmembrane transport
membrane repolarization during cardiac muscle cell action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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