Sequence of this protein is as follows: FKDACGKSED WNKVSKAESM ETLPERTKAS GEATLKKTDS CDSGITKSDL RLDNVGEARS PQDRSPILAE VKHSFYPIPE QTLQATVLEV RHELKEDIKA LNAKMTNIEK QLSEILRILT SRRSSQSPQE LFEISRPQSP ESERDIFGAS
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. KCNH1 encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. KCNH1 is activated at the onset of myoblast differentiation. KCNH1 is highly expressed in brain and in myoblasts. Overexpression of KCNH1 may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of KCNH1 results in two transcript variants encoding distinct isoforms.
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Protein Aliases: EAG channel 1; Ether-a-go-go potassium channel 1; ether-a-go-go, Drosophila, homolog of; potassium channel, voltage gated eag related subfamily H, member 1; Potassium voltage-gated channel subfamily H member 1; potassium voltage-gated channel, subfamily H (eag-related), member 1; Voltage-gated potassium channel subunit Kv10.1
Gene Aliases: EAG; EAG1; h-eag; hEAG1; KCNH1; Kv10.1; TMBTS; ZLS1
UniProt ID: (Human) O95259
Entrez Gene ID: (Human) 3756
Molecular Function: ion channel