Immunogen sequence: DLEPGEPIS NHTPCIMKVD SLTGAFLFSL ESQTTIGYGV RSITEECPHA IFLLVAQLVI TTLIEIFITG TFLAKIARPK KRAETIKFSH CAVITKQNGK LCLVIQVANM RKSLLIQCQL SGKLLQTHVT KEGERILLNQ ATVKFHVDSS SESPFLILPM TFYHVLDETS PLRDLTPQNL KEKEFELVVL LNATVESTSA VCQSRTSYIP EEIYWGFEFV PVVSLSKNGK YVADFSQFEQ IRKSPDCTFY CADSEKQQLE EKYRQEDQRE RELRTLLLQQ SNV (94-375 aa encoded by BC013327)
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
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Protein Aliases: ATP-sensitive inward rectifier potassium channel 15; Inward rectifier K(+) channel Kir1.3; Inward rectifier K(+) channel Kir4.2; inward rectifier K+ channel KIR4.2; Potassium channel, inwardly rectifying subfamily J member 15; potassium channel, inwardly rectifying subfamily J, member 15; potassium inwardly-rectifying channel, subfamily J, member 15
Gene Aliases: 4930414N08Rik; AI182284; AI267127; IRKK; KCNJ14; KCNJ15; KIR1.3; KIR4.2