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Proteintech
KCNJ3 Polyclonal Antibody
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Product Details
16985-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KCNJ3 Fusion Protein Ag10581 (147-501 aa encoded by BC022495)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GYRYITDKC PEGIILFLFQ SILGSIVDAF LIGCMFIKMS QPKKRAETLM FSEHAVISMR DGKLTLMFRV GNLRNSHMVS AQIRCKLLKS RQTPEGEFLP LDQLELDVGF STGADQLFLV SPLTIRHVID AKSPFYDLSQ RSMQTKQFEI VVILEGIVET TGMTCQARTS YTEDEVLWGH RFFPVISLEE GFFKVDYSQF HATFEVPTPP YSVKEQEEML LMSSPLIAPA ITNSKERHNS VECLDGLDDI TTKLPSKLQK ITGREDFPKK LLRMSSTTSE KAYSLGDLPM KLQRISSVPG NSEEKLVSKT TKMLSDPMSQ SVADLPPKLQ KMAGGAARME GNLPAKLRKM NSDRFT (147-501 aa encoded by BC022495)
Target Information
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein-activated inward rectifier potassium channel 1; GIRK-1; GIRK1; HGIRK1; hGIRK1c; hGIRK1d; hGIRK1e; Inward rectifier K(+) channel Kir3.1; inward rectifier K+ channel KIR3.1; KGA; KGB1; potassium channel inwarding rectifying channel subfamily J member 3; potassium channel subunit Kir3.1 type 3 delta; Potassium channel, inwardly rectifying subfamily J member 3; potassium inwardly-rectifying channel, subfamily J, member 3; potassium voltage-gated channel subfamily J member 3; unnamed protein product
Gene Aliases: GIRK-1; GIRK1; Kcnf3; KCNJ3; KGA; KIR3.1
UniProt ID: (Human) P48549, (Mouse) P63250, (Rat) P63251
Entrez Gene ID: (Human) 3760, (Mouse) 16519, (Rat) 50599
inward rectifier potassium channel activity
protein binding
phosphatidylinositol-4,5-bisphosphate binding
G-protein activated inward rectifier potassium channel activity
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
ion channel
transporter
ion transport
potassium ion transport
ion transmembrane transport
regulation of ion transmembrane transport
response to electrical stimulus
potassium ion transmembrane transport
regulation of heart rate by cardiac conduction
membrane repolarization during atrial cardiac muscle cell action potential
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of presynaptic membrane potential
ventricular cardiac muscle cell membrane repolarization
potassium ion import across plasma membrane
potassium ion import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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