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KCNJ8 Polyclonal Antibody
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Product Details
OSK00023W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the cytoplasmic domain of human KCNJ8 (Kir6.1, uKATP-1) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in rat and mouse.
Specificity of this antibody: KCNJ8.
Target Information
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. KCNJ8 is an integral membrane protein and inward-rectifier type potassium channel. KCNJ8, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-sensitive inward rectifier potassium channel 8; Inward rectifier K(+) channel Kir6.1; inwardly rectifier K(+) channel Kir6.1; Inwardly rectifying potassium channel gene subfamily J-8 (ATP sensitive); Inwardly rectifying potassium channel gene, subfamily J-8 (ATP sensitive); inwardly rectifying potassium channel KIR6.1; Potassium channel, inwardly rectifying subfamily J member 8; potassium inwardly-rectifying channel, subfamily J, member 8; potassium voltage-gated channel subfamily J member 8; uKATP-1; unnamed protein product
Gene Aliases: AI448900; gnite; KCNJ8; KIR6.1; slmbr; sltr; uKATP-1; UKATP1
UniProt ID: (Human) Q15842, (Mouse) P97794, (Rat) Q63664
Entrez Gene ID: (Human) 3764, (Mouse) 16523, (Rat) 25472
inward rectifier potassium channel activity
protein binding
ATP binding
ATP-activated inward rectifier potassium channel activity
sulfonylurea receptor binding
cation-transporting ATPase activity
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
voltage-gated ion channel activity
G-protein activated inward rectifier potassium channel activity
ion channel
transporter
action potential
blood vessel development
response to hypoxia
microglial cell activation
kidney development
vasculature development
regulation of heart rate
adaptive immune response
response to ischemia
heart morphogenesis
ventricular cardiac muscle tissue development
ion transport
potassium ion transport
apoptotic process
response to stress
inflammatory response
heart development
regulation of blood pressure
cell proliferation
determination of adult lifespan
protein secretion
response to xenobiotic stimulus
gene expression
fatty acid transport
transmission of nerve impulse
establishment of cell polarity
response to lipopolysaccharide
response to insulin
response to ATP
response to cytokine
ion transmembrane transport
regulation of ion transmembrane transport
response to endoplasmic reticulum stress
p38MAPK cascade
vasodilation
response to exogenous dsRNA
NLRP3 inflammasome complex assembly
fat cell differentiation
fibroblast proliferation
neurological system process
neuromuscular process
synaptic growth at neuromuscular junction
defense response to virus
cardiac pacemaker cell differentiation
atrioventricular node cell differentiation
coronary vasculature development
glutamate secretion, neurotransmission
CAMKK-AMPK signaling cascade
calcium ion transmembrane transport
potassium ion transmembrane transport
circulatory system development
inorganic cation transmembrane transport
membrane repolarization during ventricular cardiac muscle cell action potential
regulation of presynaptic membrane potential
reactive gliosis
transport across blood-brain barrier
response to resveratrol
potassium ion import across plasma membrane
transport
response to pH
potassium ion import
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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