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KCNK10 Antibody (PA5-115451) in ICC/IF
Immunocytochemistry analysis of KCNK10 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115451) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Product Details
PA5-115451
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KCNK10, corresponding to a region within C-terminal amino acids.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2900087
Target Information
KCNK10 is one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is highly expressed in the kidney and pancreas. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. The protein is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Three transcript variants have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2P domain potassium channel TREK2; Outward rectifying potassium channel protein TREK-2; outward rectifying potassium channel TREK2; Potassium channel subfamily K member 10; potassium channel TREK-2; potassium channel, subfamily K, member 10; potassium channel, two pore domain subfamily K, member 10; protein phosphatase 1, regulatory subunit 97; TREK-2 K(+) channel subunit; TREK-2 two-pore-domain K+ channel; TWIK-related K+ channel 2
Gene Aliases: 1700024D23Rik; 3010005K24Rik; K2p10.1; KCNK10; PPP1R97; TREK-2; TREK2
UniProt ID: (Human) P57789, (Rat) Q9JIS4
Entrez Gene ID: (Human) 54207, (Rat) 65272, (Mouse) 72258
Molecular Function:
ion channel
transporter
Performance Guarantee
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