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KCNK10 is one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is highly expressed in the kidney and pancreas. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. The protein is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Three transcript variants have been identified for this gene.
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Protein Aliases: 2P domain potassium channel TREK2; Outward rectifying potassium channel protein TREK-2; outward rectifying potassium channel TREK2; Potassium channel subfamily K member 10; potassium channel TREK-2; potassium channel, subfamily K, member 10; potassium channel, two pore domain subfamily K, member 10; protein phosphatase 1, regulatory subunit 97; TREK-2 K(+) channel subunit; TREK-2 two-pore-domain K+ channel; TWIK-related K+ channel 2
Gene Aliases: 1700024D23Rik; 3010005K24Rik; K2p10.1; KCNK10; PPP1R97; TREK-2; TREK2