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A suggested positive control is rat brain tissue lysate.
PA5-20873 can be used with blocking peptide PEP-0987.
TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.
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Protein Aliases: 2P K ion channel TRESK; Potassium channel subfamily K member 18; potassium channel, subfamily K, member 18; potassium channel, two pore domain subfamily K, member 18; tandem-pore K+ (K(2P)) channel; Tresk-2; TWIK-related individual K+ channel; TWIK-related individual potassium channel; TWIK-related spinal cord K+ channel; TWIK-related spinal cord potassium channel; Two-pore-domain potassium channel TRESK
Gene Aliases: Gm781; K2p18.1; KCNK18; MGR13; TRESK; TRESK-2; TRESK2; TRIK