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Osenses
KCNK2 Polyclonal Antibody
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Product Details
OSK00038W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from human KCNK2 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat and mouse.
Specificity of this antibody: KCNK2.
Target Information
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: arachidonic acid sensitive tandem pore domain potassium channel; ion transport membrane protein; K2P2.1; K2P2.1 potassium channel; kcnk2 {ECO:0000312|EMBL:AAU06141.1, ECO:0000312|Ensembl:ENSRNOP00000003684, ECO:0000312|RGD:621448}; Outward rectifying potassium channel protein TREK-1; outward rectifying potassium channel protein TREK-1 {ECO:0000250|UniProtKB:O95069}; Potassium channel subfamily K member 2; potassium channel subfamily k member 2 variant 1; potassium channel subfamily k member 2 variant 2; potassium channel subfamily K member 2 {ECO:0000250|UniProtKB:O95069}; potassium channel, subfamily K, member 2; potassium channel, two pore domain subfamily K, member 2; potassium inwardly-rectifying channel, subfamily K, member 2; Stretch-activated potassium channel TREK-1; stretch-activated potassium channel TREK-1 {ECO:0000303|PubMed:16248991}; tandem-pore-domain potassium channel TREK-1; trek 1; TREK-1 K(+) channel subunit; TREK-1 K(+) channel subunit {ECO:0000250|UniProtKB:O95069}; TWIK-related potassium channel 1; Two pore domain potassium channel TREK-1; two pore domain potassium channel TREK-1 {ECO:0000303|PubMed:24196565}; Two pore domain potassium channel TREK1; Two pore potassium channel TPKC1; two pore potassium channel TPKC1 {ECO:0000250|UniProtKB:O95069}; two-pore potassium channel 1
Gene Aliases: A430027H14Rik; AI848635; hTREK-1c; hTREK-1e; K2p2.1; KCNK2; rTREK1d; TPKC1; TREK; TREK-1; TREK1
UniProt ID: (Human) O95069, (Rat) Q920B6, (Mouse) P97438
Entrez Gene ID: (Human) 3776, (Rat) 170899, (Mouse) 16526
cardiac ventricle development
G-protein coupled receptor signaling pathway
memory
response to mechanical stimulus
positive regulation of cell death
stabilization of membrane potential
response to axon injury
negative regulation of cardiac muscle cell proliferation
cellular response to hypoxia
potassium ion transmembrane transport
cochlea development
positive regulation of cellular response to hypoxia
negative regulation of DNA biosynthetic process
potassium ion transport
regulation of membrane potential
transport
ion transport
regulation of ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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