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Invitrogen
KCNK2 Polyclonal Antibody
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FIGURE: 1 / 2
KCNK2 Antibody (PA5-111815) in IHC (F)
Immunohistochemistry analysis of KCNK2 in perfusion-fixed, frozen rat midbrain tissue sections using KCNK2 Antibody (Product # PA5-111815) at a dilution of 1:400, followed by goat-anti-guinea pig-Cy3 antibody. TREK-1 staining (red) appears in neurons in the rat lateral substantia nigra (arrows). Nuclei are stained with DAPI (blue).
Product Details
PA5-111815
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to residues 8-25 of human KCNK2 (Intracellular, N-terminus)
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
Product Specific Information
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: DPKSAAQNSK PRLSFSTK(C )
Homology: Rat amino acid residues identical; mouse - 17/18 amino acidresidues identical.
Target Information
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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