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KCNK2 Antibody (PA5-115452) in IHC (P)
Immunohistochemistry analysis of KCNK2 in mouse kidney tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115452) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-115452
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KCNK2, corresponding to a region within N-terminal amino acids.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
RRID
AB_2900088
Target Information
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: arachidonic acid sensitive tandem pore domain potassium channel; ion transport membrane protein; K2P2.1 potassium channel; kcnk2 {ECO:0000312|EMBL:AAU06141.1, ECO:0000312|Ensembl:ENSRNOP00000003684, ECO:0000312|RGD:621448}; Outward rectifying potassium channel protein TREK-1; outward rectifying potassium channel protein TREK-1 {ECO:0000250|UniProtKB:O95069}; Potassium channel subfamily K member 2; potassium channel subfamily k member 2 variant 1; potassium channel subfamily k member 2 variant 2; potassium channel subfamily K member 2 {ECO:0000250|UniProtKB:O95069}; potassium channel, subfamily K, member 2; potassium channel, two pore domain subfamily K, member 2; potassium inwardly-rectifying channel, subfamily K, member 2; Stretch-activated potassium channel TREK-1; stretch-activated potassium channel TREK-1 {ECO:0000303|PubMed:16248991}; tandem-pore-domain potassium channel TREK-1; trek 1; TREK-1 K(+) channel subunit; TREK-1 K(+) channel subunit {ECO:0000250|UniProtKB:O95069}; TWIK-related potassium channel 1; Two pore domain potassium channel TREK-1; two pore domain potassium channel TREK-1 {ECO:0000303|PubMed:24196565}; Two pore potassium channel TPKC1; two pore potassium channel TPKC1 {ECO:0000250|UniProtKB:O95069}; two-pore potassium channel 1
Gene Aliases: A430027H14Rik; AI848635; hTREK-1c; hTREK-1e; K2p2.1; KCNK2; rTREK1d; TPKC1; TREK; TREK-1; TREK1
UniProt ID: (Human) O95069, (Rat) Q920B6, (Mouse) P97438
Entrez Gene ID: (Human) 3776, (Rat) 170899, (Mouse) 16526
Molecular Function:
ion channel
transporter
cardiac ventricle development
G-protein coupled receptor signaling pathway
memory
response to mechanical stimulus
positive regulation of cell death
stabilization of membrane potential
response to axon injury
negative regulation of cardiac muscle cell proliferation
cellular response to hypoxia
potassium ion transmembrane transport
cochlea development
positive regulation of cellular response to hypoxia
negative regulation of DNA biosynthetic process
potassium ion transport
regulation of membrane potential
transport
ion transport
regulation of ion transmembrane transport
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