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Invitrogen
KCNK3 Polyclonal Antibody
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Product Details
PA5-41011
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the C-terminal of human KCNK3 (aa 338-387).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: TCVEQSHSSP GGGGRYSDTP SRRCLCSGAP RSAISSVSTG LHSLSTFRGL
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Sheep: 100%
Target Information
KCNK3 encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The gene product is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: acid-sensitive potassium channel protein TASK; Acid-sensitive potassium channel protein TASK-1; cardiac potassium channel; Cardiac two pore background K(+) channel; cTBAK 1; cTBAK-1; KCNK9; Potassium channel subfamily K member 3; potassium channel, two pore domain subfamily K, member 3; potassium inwardly-rectifying channel, subfamily K, member 3; TASK 1; TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; two P domain potassium channel; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1
Gene Aliases: Ctbak; cTBAK-1; K2p3.1; KCNK3; OAT1; PPH4; TASK; TASK-1; TASK1; TBAK1
UniProt ID: (Human) O14649, (Mouse) O35111
Entrez Gene ID: (Human) 3777, (Mouse) 16527
ion channel activity
open rectifier potassium channel activity
potassium channel activity
protein C-terminus binding
potassium ion leak channel activity
protein homodimerization activity
S100 protein binding
protein heterodimerization activity
voltage-gated ion channel activity
ion channel
transporter
potassium ion transport
chemical synaptic transmission
brain development
stabilization of membrane potential
ion transmembrane transport
response to drug
negative regulation of cytosolic calcium ion concentration
cardiac conduction
cellular response to zinc ion
cellular response to hypoxia
potassium ion transmembrane transport
cochlea development
mitophagy in response to mitochondrial depolarization
transport
ion transport
regulation of ion transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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