Immunogen sequence: TLLRSYMQSV WTEESQCTLL NASITETFNC SFSCGPDCWK LSQYPCLQVY VNLTSSGEKL LLYHTEETIK INQKCSYIPK CGKNFEESMS LVNVVMENFR KYQHFSCYSD PEGNQKSVIL TKLYSSN; Positive Samples: Mouse kidney, Mouse brain, Mouse lung, Rat brain, Rat kidney; Cellular Location: Membrane, Multi-pass membrane protein
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described.
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Protein Aliases: big potassium channel beta subunit 2; BK channel beta subunit 2; BK channel subunit beta-2; BKbeta2; calcium-activated potassium channel beta 2; Calcium-activated potassium channel subunit beta-2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; hbeta2; Hbeta3; hCG1646471; K(VCA)beta-2; large conductance calcium-activated potassium channel beta 2 subunit; large-conductance Ca2+-activated K+ channel beta2 subunit; Maxi K channel subunit beta-2; MaxiK channel beta 2 subunit; MaxiK channel beta-subunit 2; potassium channel subfamily M regulatory beta subunit 2; potassium large conductance calcium-activated channel, subfamily M, beta member 2; Rbeta3; Slo-beta-2
Gene Aliases: 2700049B16Rik; 3110031N04Rik; Kcmb2; KCNMB2