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Product Details
PA5-41013
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1.25 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide directed towards the C-terminal of human KCNN1 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
Protein A |
Storage buffer |
PBS with 2% sucrose |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2606228 |
Product Specific Information
Peptide sequence: KIEQGKLNDQ ANTLTDLAKT QTVMYDLVSE LHAQHEELEA RLATLESRLD
Sequence homology: Cow: 93%; Dog: 93%; Guinea Pig: 79%; Horse: 92%; Human: 100%; Pig: 93%; Rat: 85%
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN1 is a member of the KCNN family of potassium channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KCa2.1; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1; SK1; small conductance calcium-activated potassium channel 1; Small conductance calcium-activated potassium channel protein 1
Gene Aliases: hSK1; KCa2.1; KCNN1; SK; SK1; SKCA1
UniProt ID: (Human) Q92952
Entrez Gene ID: (Human) 3780
Molecular Function:
voltage-gated ion channel
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