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Invitrogen
KCNN2 Polyclonal Antibody
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FIGURE: 1 / 7
KCNN2 Antibody (PA5-114347) in IHC (P)
Immunohistochemical analysis of KCNN2 in paraffin-embedded rat cerebellar tissue using a polyclonal antibody (Product #PA5-114347). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:200) for 30 minute... View More
Product Details
PA5-114347
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within rat KCNN2 aa 531-580.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Action potentials in vertebrate neurons are followed by an afterhyperpolarization that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apamin-sensitive small-conductance Ca2+-activated potassium channel; KCa2.2; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; SK2; SKCa 2; SKCa2; small conductance calcium-activated channel, subfamily N, member 2; small conductance calcium-activated potassium channel 2; Small conductance calcium-activated potassium channel protein 2; small conductance calcium-activated potassium channel subfamily N member 2
Gene Aliases: fri; hSK2; KCa2.2; KCNN2; SK2; SKCa 2; SKCA2
UniProt ID: (Human) Q9H2S1, (Rat) P70604, (Mouse) P58390
Entrez Gene ID: (Human) 3781, (Rat) 54262, (Mouse) 140492
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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