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Alomone Labs, LTD
KCNQ2 Polyclonal Antibody
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Product Details
APC-050-200UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)RGPTITDKDRTKGPAE, corresponding to amino acid residues 578-593 of rat KCNQ2, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system and KNCQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: KQT like 2; KQT-like 2; KVEBN1; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Potassium channel subunit alpha KvLQT2; potassium channel, voltage gated KQT-like subfamily Q, member 2; Potassium voltage-gated channel subfamily KQT member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; potassium voltage-gated channel, subfamily Q, member 2; unnamed protein product; Voltage-gated potassium channel subunit Kv7.2
Gene Aliases: BFNC; DEE7; EBN; EBN1; ENB1; HNSPC; KCNA11; KCNQ2; KQT2; KV7.2; Nmf134
UniProt ID: (Human) O43526, (Rat) O88943, (Mouse) Q9Z351
Entrez Gene ID: (Human) 3785, (Rat) 170848, (Mouse) 16536
action potential
ion transport
potassium ion transport
chemical synaptic transmission
nervous system development
ion transmembrane transport
transmembrane transport
potassium ion transmembrane transport
transmission of nerve impulse
regulation of ion transmembrane transport
membrane hyperpolarization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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