Search
Invitrogen
KCNQ3 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
KCNQ3 Antibody (PA1-930) in ICC/IF
Immunofluorescence analysis of KCNQ3 was performed using 70% confluent log phase RSC-96 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with KCNQ3 Rabbit Polyclonal Antibody (Product # PA1-930) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A2... View More
Product Details
PA1-930
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
GST fusion protein encoding the first 71 amino acids of rat KCNQ3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-930 detects KCNQ3 from mouse, human and rat samples. This antibody is specific for KCNQ3 and does not detect KCNQ1, KCNQ2, KCNQ4 or KCNQ5.
PA1-930 has been successfully used in immunofluorescence, immunohistochemistry and immunocytochemistry procedures. Immunohistochemical staining using PA1-930 yielded a strong signal mainly in interneurons and astrocytes in the dentate region of rat hippocampal samples.
PA1-930 immunogen is a GST fusion protein encoding the first 71 amino acids of rat KCNQ3.
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KCNQs (KCNQ1-5) found in the central nervous system and KCNQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BFNC; KQT-like 3; Potassium channel subunit alpha KvLQT3; potassium channel, voltage gated KQT-like subfamily Q, member 3; potassium channel, voltage-gated, subfamily Q, member 3; Potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; potassium voltage-gated channel, subfamily Q, member 3; unnamed protein product; Voltage-gated potassium channel subunit Kv7.3
Gene Aliases: BFNC2; EBN2; KCNQ3; KV7.3
UniProt ID: (Human) O43525, (Rat) O88944, (Mouse) Q8K3F6
Entrez Gene ID: (Human) 3786, (Rat) 29682, (Mouse) 110862
ion channel activity
voltage-gated ion channel activity
voltage-gated potassium channel activity
potassium channel activity
protein binding
calmodulin binding
voltage-gated cation channel activity
delayed rectifier potassium channel activity
protein kinase binding
ubiquitin protein ligase binding
ion channel binding
voltage-gated ion channel
protein targeting
protein import into nucleus
ion transport
potassium ion transport
exocytosis
endocytosis
chemical synaptic transmission
sensory perception of sound
response to mechanical stimulus
gene expression
response to auditory stimulus
protein transport
neuron remodeling
neuronal action potential
nerve development
neuron differentiation
ion transmembrane transport
psychomotor behavior
regulation of synaptic plasticity
neuron apoptotic process
establishment of localization in cell
mitochondrial depolarization
transmembrane transport
membrane hyperpolarization
protein-containing complex assembly
cellular response to calcium ion
cellular response to xenobiotic stimulus
potassium ion transmembrane transport
apoptosome assembly
excitatory chemical synaptic transmission
inhibitory chemical synaptic transmission
action potential initiation
regulation of action potential firing threshold
substantia propria of cornea development
oligodendrocyte development
regulation of ion transmembrane transport
ganglion development
cellular response to ammonium ion
transport
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support