Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Sequence homology: Cow: 79%; Dog: 79%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 86%; Rat: 93%
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KCNQs (KCNQ1-5) found in the central nervous system and KCNQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
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Protein Aliases: BFNC; KQT-like 3; Potassium channel subunit alpha KvLQT3; Potassium voltage-gated channel subfamily KQT member 3; Voltage-gated potassium channel subunit Kv7.3
Gene Aliases: Kcnq3
UniProt ID: (Mouse) Q8K3F6
Entrez Gene ID: (Mouse) 110862
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