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KCTD11 Polyclonal Antibody
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Product Details
BS-9637R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human KCTD11.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Calponin, a thin filament associated protein is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. Calponin is expressed in smooth muscle and tissues containing significant amounts of smooth muscle. Two isoforms of calponin exist whose molecular weights are 34kDa and 29kDa. Expression of the 29kDa form is primarily restricted to muscle of the urogenital tract. The expression of calponin has also been demonstrated in myoepithelial cells from benign and malignant breast lesions. It stains smooth muscle, myoepithelial cells, myofibroblasts, keratinocytes and nerve fibers. It identifies myoepithelial cells in breast lesions, and helps differentiate breast collagenous spherulosis (positive) from adenoid cystic carcinoma. Adenoid cystic carcinoma in salivary gland tumors is calponin positive.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BTB/POZ domain-containing protein KCTD11; KCASH1 protein; potassium channel tetramerisation domain containing 11; Potassium channel tetramerization domain-containing protein 11; retinoic acid, EGF, and NGF upregulated; retinoic acid, EGF, NGF induced gene protein; RING-type E3 ubiquitin transferase subunit KCTD11; unnamed protein product
Gene Aliases: AF465352; C17orf36; KCASH1; KCTD11; REN; REN/KCTD11
UniProt ID: (Human) Q693B1, (Mouse) Q8K485
Entrez Gene ID: (Human) 147040, (Mouse) 216858, (Rat) 363634
smoothened signaling pathway
nervous system development
neuroblast proliferation
negative regulation of neuroblast proliferation
neuroblast differentiation
protein ubiquitination
neuron differentiation
regulation of cell proliferation
positive regulation of neuron differentiation
negative regulation of smoothened signaling pathway
protein homooligomerization
cell cycle
multicellular organism development
cell differentiation
regulation of growth
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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