Peptide sequence: PGPAAYGLKP LTPNSKYVKL NVGGSLHYTT LRTLTGQDTM LKAMFSGRVE
Sequence homology: Cow: 93%; Dog: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%
Cytochrome P450 super family proteins are monooxygenases which catalyze multiple biochemical reactions involved in drug metabolism and synthesis of cholesterol, steroids and lipids. CYP4F3, a 60KDa protein, is a novel member of this family. It consists of a conserved heme-binding domain near the C-terminus and catalyzes the u-hydroxylation of LTB4. CYP4F3 is localized in the ER and plays a vital role in the inactivation of LTB4 and controlling inflammation. CYP4F3 exists in two functionally distinct isoforms: CYP4F3A, a neutrophil isoform, is particularly expressed in neutrophils and myeloid cells and catalyzes the microsomal u-hydroxylation of LTB4. It interacts with CD11b and myeloperoxidase on myeloid cells and regulates cellular development in bone marrow. CYP4F3B, a liver isoform, catalyzes the conversion of arachidonic acid to 20-HETE, a potent activator of PKC. Itrole hasbeen implicatedin cell proliferation, vascular tone and natriuresis.
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Protein Aliases: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; BTB/POZ domain-containing protein KCTD13; CTD-2574D22.4; hBACURD1; PDIP1; Polymerase delta-interacting protein 1; potassium channel tetramerisation domain containing 13; potassium channel tetramerisation domain containing 13-like; TNFAIP1-like protein; tumor necrosis factor alpha-inducible protein PDIP1
Gene Aliases: 1500003N18Rik; AV259508; BACURD1; BOS_22863; FKSG86; hBACURD1; KCTD13; PDIP1; PDIP1alpha; POLDIP1; PP6832