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Invitrogen
KChIP2 Polyclonal Antibody
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Product Details
PA5-41075
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human KCNIP2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Peptide sequence: QLTDSVDDEF ELSTVCHRPE GLEQLQEQTK FTRKELQVLY RGFKNPGALS
Sequence homology: Cow: 100%; Dog: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein KCNIP2; Cardiac voltage-gated potassium channel modulatory subunit; DKFZp566L1246; KChIP2; KChlP2; Kv channel interacting protein 2; Kv channel-interacting protein 2; MGC17241; Potassium channel-interacting protein 2
Gene Aliases: KCHIP2; KCNIP2
UniProt ID: (Human) Q9NS61, (Mouse) Q9JJ69
Entrez Gene ID: (Human) 30819, (Mouse) 80906
A-type (transient outward) potassium channel activity
calcium ion binding
protein binding
potassium channel regulator activity
ion channel binding
ER retention sequence binding
protein N-terminus binding
voltage-gated ion channel activity
potassium channel activity
identical protein binding
metal ion binding
transport
ion transport
potassium ion transport
regulation of ion transmembrane transport
clustering of voltage-gated potassium channels
potassium ion export
potassium ion transmembrane transport
membrane repolarization
regulation of potassium ion transmembrane transport
detection of calcium ion
muscle contraction
signal transduction
chemical synaptic transmission
regulation of heart contraction
cardiac conduction
regulation of cation channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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