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Proteintech
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Immunogen sequence: QKQRTKPLI PEMCFTSTGC STDINLSTPY LEEDGTSILV SCKKCSVRVH ASCYGVPPAK ASEDWMCSRC SANALEEDCC LCSLRGGALQ RANDDRWVHV SCAVAILEAR FVNIAERSPV DVSKIPLPRF KLKCIFCKKR RKRTAGCCVQ CSHGRCPTAF HVSCAQAAGV MMQPDDWPFV VFITCFRHKI PNLERAKGAL QSITAGQKVI SKHKNGRFYQ CEVVRLTTET FYEVNFDDGS FSDNLYPEDI VSQDCLQFGP PAEGEVVQVR WTDGQVYGAK FVASHPIQMY QVEFEDGSQL VVKRDDVYTL DEELPKRVKS RLSVASDMRF NEIFTEKEVK QEKKRQRVIN SRYREDYIEP ALYRAIME (698-1064 aa encoded by BC002558)
JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
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