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Invitrogen
KDM5B Polyclonal Antibody
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Product Details
PA5-50693
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to a region derived from internal residues of human lysine (K)-specific demethylase 5B
Conjugate
Form
Liquid
Concentration
2.7 mg/mL
Amount
270 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody detects endogenous levels of total KDM5B protein.
Target Information
KDM5B is a histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. KDM5B demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. It acts as a transcriptional corepressor for FOXG1B and PAX9. It favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, KDM5B may act as a tumor suppressor for melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-trimethyl-L-lysine(4) demethylase 5B; Cancer/testis antigen 31; CT31; Histone demethylase JARID1B; HRIHFB2060; jumonji, AT rich interactive domain 1B; jumonji, AT rich interactive domain 1B (Rbp2 like); Jumonji/ARID domain-containing protein 1B; lysine (K)-specific demethylase 5B; Lysine-specific demethylase 5B; PLU-1; protein phosphatase 1, regulatory subunit 98; putative DNA/chromatin binding motif; putative DNA/chromatin binding motif 1; RBP2-H1; Retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A; unnamed protein product
Gene Aliases: 2010009J12Rik; 2210016I17Rik; AW556288; CT31; D1Ertd202e; JARID1B; KDM5B; Kiaa4034; mKIAA4034; MRT65; PLU-1; PLU1; PPP1R98; PUT1; Rb-Bp2; RBBP2H1; RBBP2H1A; RBP2-H1
UniProt ID: (Human) Q9UGL1, (Mouse) Q80Y84
Entrez Gene ID: (Human) 10765, (Mouse) 75605
nucleic acid binding
DNA binding
transcription corepressor activity
protein binding
zinc ion binding
oxidoreductase activity
histone demethylase activity
histone demethylase activity (H3-K4 specific)
histone demethylase activity (H3-trimethyl-K4 specific)
histone binding
metal ion binding
dioxygenase activity
sequence-specific double-stranded DNA binding
sulfonate dioxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
histone demethylase activity (H3-dimethyl-K4 specific)
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
histone modifying enzyme
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
single fertilization
post-embryonic development
positive regulation of gene expression
positive regulation of mammary gland epithelial cell proliferation
cellular response to fibroblast growth factor stimulus
negative regulation of transcription, DNA-templated
rhythmic process
branching involved in mammary gland duct morphogenesis
mammary duct terminal end bud growth
response to fungicide
uterus morphogenesis
lens fiber cell differentiation
cellular response to leukemia inhibitory factor
regulation of estradiol secretion
transcription, DNA-templated
chromatin modification
histone H3-K4 demethylation
histone H3-K4 demethylation, trimethyl-H3-K4-specific
regulation of circadian rhythm
oxidation-reduction process
negative regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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