This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human KEAP1.
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cytosolic inhibitor of Nrf2; INrf2; Kelch-like ECH-associated protein 1; kelch-like family member 19; Kelch-like protein 19; NRF2 cytosolic inhibitor; ring canal protein
Gene Aliases: INRF2; KEAP1; KIAA0132; KLHL19; mKIAA0132
Molecular Function: scaffold/adaptor protein