Product References
p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas.
American journal of cancer research
Arai A,Chano T,Ikebuchi K,Hama Y,Ochi Y,Tameno H,Shimada T
Thu Oct 01 00:00:00 EDT 2020
Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice.
Frontiers in pharmacology
Liu J,Li W,Limbu MH,Li Y,Wang Z,Cheng Z,Zhang X,Chen P
Wed Sep 30 00:00:00 EDT 2020
Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice.
Frontiers in pharmacology
Liu J,Li W,Limbu MH,Li Y,Wang Z,Cheng Z,Zhang X,Chen P
Wed Sep 30 00:00:00 EDT 2020
Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes.
Frontiers in physiology
Liu J,Li Y,Liu L,Wang Z,Shi C,Cheng Z,Zhang X,Ding F,Chen PS
Wed Sep 30 00:00:00 EDT 2020
Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes.
Frontiers in physiology
Liu J,Li Y,Liu L,Wang Z,Shi C,Cheng Z,Zhang X,Ding F,Chen PS
Wed Sep 30 00:00:00 EDT 2020
Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats.
Frontiers in pharmacology
Cai SA,Hou N,Zhao GJ,Liu XW,He YY,Liu HL,Hua YQ,Li LR,Huang Y,Ou CW,Luo CF,Chen MS
Tue Sep 29 00:00:00 EDT 2020
Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.
PloS one
Kanamoto M,Tsuchiya Y,Nakao Y,Suzuki T,Motohashi H,Yamamoto M,Kamata H
Mon Apr 01 00:00:00 EDT 2019
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
The Journal of reproduction and development
Ullah O,Li Z,Ali I,Xu L,Liu H,Shah SZA,Fang N
Fri Feb 08 00:00:00 EST 2019
Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities.
Phytochemistry
Qiao YN,Sun Y,Shen T,Zhang JZ,Zhou JC,Li Y,Chen W,Ren ZJ,Li YL,Wang X,Lou HX
Fri Feb 01 00:00:00 EST 2019
Nrf2 protects stellate cells from Smad-dependent cell activation.
PloS one
Prestigiacomo V,Suter-Dick L
Mon Jan 14 00:00:00 EST 2019
Nrf2 protects stellate cells from Smad-dependent cell activation.
PloS one
Prestigiacomo V,Suter-Dick L
Mon Jan 14 00:00:00 EST 2019
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Cancer cell
Karras P,Riveiro-Falkenbach E,Cañón E,Tejedo C,Calvo TG,Martínez-Herranz R,Alonso-Curbelo D,Cifdaloz M,Perez-Guijarro E,Gómez-López G,Ximenez-Embun P,Muñoz J,Megias D,Olmeda D,Moscat J,Ortiz-Romero PL,Rodríguez-Peralto JL,Soengas MS
Mon Jan 14 00:00:00 EST 2019
Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.
American journal of hematology
Beneduce E,Matte A,De Falco L,Mbiandjeu S,Chiabrando D,Tolosano E,Federti E,Petrillo S,Mohandas N,Siciliano A,Babu W,Menon V,Ghaffari S,Iolascon A,De Franceschi L
Tue Jan 01 00:00:00 EST 2019
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Journal of molecular neuroscience : MN
Yang Q,Lin J,Zhang H,Liu Y,Kan M,Xiu Z,Chen X,Lan X,Li X,Shi X,Li N,Qu X
Tue Jan 01 00:00:00 EST 2019
A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.
PloS one
Adams O,Janser FA,Dislich B,Berezowska S,Humbert M,Seiler CA,Kroell D,Slotta-Huspenina J,Feith M,Ott K,Tschan MP,Langer R
Tue Dec 11 00:00:00 EST 2018
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Free radical biology & medicine
Shin D,Kim EH,Lee J,Roh JL
Sat Dec 01 00:00:00 EST 2018
Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice.
Phytotherapy research : PTR
Li Y,Fu S,Li E,Sun X,Xu H,Meng Y,Wang X,Chen Y,Xie C,Geng S,Wu J,Zhong C,Xu P
Sat Dec 01 00:00:00 EST 2018
Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.
Cell reports
Cai J,Pires KM,Ferhat M,Chaurasia B,Buffolo MA,Smalling R,Sargsyan A,Atkinson DL,Summers SA,Graham TE,Boudina S
Tue Nov 13 00:00:00 EST 2018
Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.
Cancer discovery
Eckhardt M,Zhang W,Gross AM,Von Dollen J,Johnson JR,Franks-Skiba KE,Swaney DL,Johnson TL,Jang GM,Shah PS,Brand TM,Archambault J,Kreisberg JF,Grandis JR,Ideker T,Krogan NJ
Thu Nov 01 00:00:00 EDT 2018
Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network.
Cancer discovery
Eckhardt M,Zhang W,Gross AM,Von Dollen J,Johnson JR,Franks-Skiba KE,Swaney DL,Johnson TL,Jang GM,Shah PS,Brand TM,Archambault J,Kreisberg JF,Grandis JR,Ideker T,Krogan NJ
Thu Nov 01 00:00:00 EDT 2018
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Journal of cellular biochemistry
Zhang X,Li X,Fang J,Hou X,Fang H,Guo F,Li F,Chen A,Huang S
Thu Nov 01 00:00:00 EDT 2018
Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response.
Oxidative medicine and cellular longevity
Li YR,Li GH,Sun L,Li L,Liu Y,Kong DG,Wang SQ,Ren DM,Wang XN,Lou HX,Shen T
Mon Oct 22 00:00:00 EDT 2018
Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease.
Cell metabolism
Yamada T,Murata D,Adachi Y,Itoh K,Kameoka S,Igarashi A,Kato T,Araki Y,Huganir RL,Dawson TM,Yanagawa T,Okamoto K,Iijima M,Sesaki H
Tue Oct 02 00:00:00 EDT 2018
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Regulatory toxicology and pharmacology : RTP
Ning C,Gao X,Wang C,Kong Y,Liu Z,Sun H,Sun P,Huo X,Ma X,Meng Q,Liu K
Mon Oct 01 00:00:00 EDT 2018
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
Bioorganic & medicinal chemistry
Li YR,Li GH,Zhou MX,Xiang L,Ren DM,Lou HX,Wang XN,Shen T
Mon Oct 01 00:00:00 EDT 2018
Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.
Toxicology and applied pharmacology
Yang B,Cheng H,Wang L,Fu J,Zhang G,Guan D,Qi R,Gao X,Zhao R
Sat Sep 15 00:00:00 EDT 2018
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Journal of applied toxicology : JAT
Li Y,Qian W,Wang D,Meng Y,Wang X,Chen Y,Li X,Xie C,Zhong C,Fu S
Sat Sep 01 00:00:00 EDT 2018
Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.
Acta pharmacologica Sinica
Li ST,Dai Q,Zhang SX,Liu YJ,Yu QQ,Tan F,Lu SH,Wang Q,Chen JW,Huang HQ,Liu PQ,Li M
Wed Aug 01 00:00:00 EDT 2018
dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer.
Cell proliferation
Hu Q,Qin Y,Xiang J,Liu W,Xu W,Sun Q,Ji S,Liu J,Zhang Z,Ni Q,Xu J,Yu X,Zhang B
Wed Aug 01 00:00:00 EDT 2018
Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells.
Scientific reports
Endo H,Owada S,Inagaki Y,Shida Y,Tatemichi M
Wed Jul 04 00:00:00 EDT 2018
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
Redox biology
Zhao L,Tao X,Qi Y,Xu L,Yin L,Peng J
Fri Jun 01 00:00:00 EDT 2018
Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy.
Thoracic cancer
Zhang J,Jiao Q,Kong L,Yu J,Fang A,Li M,Yu J
Fri Jun 01 00:00:00 EDT 2018
Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway.
Food & function
Bi W,He CN,Li XX,Zhou LY,Liu RJ,Zhang S,Li GQ,Chen ZC,Zhang PF
Wed May 23 00:00:00 EDT 2018
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Liang M,Wang Z,Li H,Cai L,Pan J,He H,Wu Q,Tang Y,Ma J,Yang L
Tue May 01 00:00:00 EDT 2018
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
Nature
Chen J,Ou Y,Yang Y,Li W,Xu Y,Xie Y,Liu Y
Tue May 01 00:00:00 EDT 2018
Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells.
Redox biology
Zhou MX,Li GH,Sun B,Xu YW,Li AL,Li YR,Ren DM,Wang XN,Wen XS,Lou HX,Shen T
Sun Apr 01 00:00:00 EDT 2018
Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-κB, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Zhou MM,Zhang WY,Li RJ,Guo C,Wei SS,Tian XM,Luo J,Kong LY
Thu Mar 15 00:00:00 EDT 2018
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Toxicology letters
Qiao Y,Xu L,Tao X,Yin L,Qi Y,Xu Y,Han X,Tang Z,Ma X,Liu K,Peng J
Thu Mar 01 00:00:00 EST 2018
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
International immunopharmacology
Jia YN,Lu HP,Peng YL,Zhang BS,Gong XB,Su J,Zhou Y,Pan MH,Xu L
Thu Mar 01 00:00:00 EST 2018
Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice.
Chemico-biological interactions
Shen Z,Wang Y,Su Z,Kou R,Xie K,Song F
Sun Feb 25 00:00:00 EST 2018
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.
European journal of medicinal chemistry
Lu M,Liu T,Jiao Q,Ji J,Tao M,Liu Y,You Q,Jiang Z
Sun Feb 25 00:00:00 EST 2018
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.
European journal of medicinal chemistry
Lu M,Liu T,Jiao Q,Ji J,Tao M,Liu Y,You Q,Jiang Z
Sun Feb 25 00:00:00 EST 2018
Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway.
European journal of medicinal chemistry
Lu M,Liu T,Jiao Q,Ji J,Tao M,Liu Y,You Q,Jiang Z
Sun Feb 25 00:00:00 EST 2018
Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis.
Molecular cell
Zhao D,Badur MG,Luebeck J,Magaña JH,Birmingham A,Sasik R,Ahn CS,Ideker T,Metallo CM,Mali P
Thu Feb 15 00:00:00 EST 2018
CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.
Free radical biology & medicine
Gong W,Chen Z,Zou Y,Zhang L,Huang J,Liu P,Huang H
Thu Feb 01 00:00:00 EST 2018
Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy.
Nature cell biology
An H,Harper JW
Thu Feb 01 00:00:00 EST 2018
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Environmental toxicology
Lin EY,Bayarsengee U,Wang CC,Chiang YH,Cheng CW
Mon Jan 01 00:00:00 EST 2018
Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses.
The Journal of cell biology
Hos NJ,Ganesan R,Gutiérrez S,Hos D,Klimek J,Abdullah Z,Krönke M,Robinson N
Mon Dec 04 00:00:00 EST 2017
The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-β1 expressions in rat glomerular mesangial cells.
Experimental cell research
Huang K,Gao X,Wei W
Fri Dec 01 00:00:00 EST 2017
Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis.
The American journal of pathology
Anzovino A,Chiang S,Brown BE,Hawkins CL,Richardson DR,Huang ML
Fri Dec 01 00:00:00 EST 2017
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
Cancer cell
Ge W,Zhao K,Wang X,Li H,Yu M,He M,Xue X,Zhu Y,Zhang C,Cheng Y,Jiang S,Hu Y
Mon Nov 13 00:00:00 EST 2017
iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding.
Cancer cell
Ge W,Zhao K,Wang X,Li H,Yu M,He M,Xue X,Zhu Y,Zhang C,Cheng Y,Jiang S,Hu Y
Mon Nov 13 00:00:00 EST 2017
SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis.
Oncotarget
Huang R,Li X,Yu Y,Ma L,Liu S,Zong X,Zheng Q
Tue Nov 07 00:00:00 EST 2017
miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1.
Molecular cancer research : MCR
Akdemir B,Nakajima Y,Inazawa J,Inoue J
Wed Nov 01 00:00:00 EDT 2017
A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.
Journal of cell science
O'Mealey GB,Plafker KS,Berry WL,Janknecht R,Chan JY,Plafker SM
Sun Oct 15 00:00:00 EDT 2017
A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.
Journal of cell science
O'Mealey GB,Plafker KS,Berry WL,Janknecht R,Chan JY,Plafker SM
Sun Oct 15 00:00:00 EDT 2017
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.
Autophagy
Mildenberger J,Johansson I,Sergin I,Kjøbli E,Damås JK,Razani B,Flo TH,Bjørkøy G
Tue Oct 03 00:00:00 EDT 2017
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.
Autophagy
Mildenberger J,Johansson I,Sergin I,Kjøbli E,Damås JK,Razani B,Flo TH,Bjørkøy G
Tue Oct 03 00:00:00 EDT 2017
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.
Autophagy
Mildenberger J,Johansson I,Sergin I,Kjøbli E,Damås JK,Razani B,Flo TH,Bjørkøy G
Tue Oct 03 00:00:00 EDT 2017
CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells.
Oncogene
Wang Q,Ma J,Lu Y,Zhang S,Huang J,Chen J,Bei JX,Yang K,Wu G,Huang K,Chen J,Xu S
Thu Sep 14 00:00:00 EDT 2017
Exogenous H2S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Cell death & disease
Wu J,Tian Z,Sun Y,Lu C,Liu N,Gao Z,Zhang L,Dong S,Yang F,Zhong X,Xu C,Lu F,Zhang W
Thu Aug 10 00:00:00 EDT 2017
Exogenous H2S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Cell death & disease
Wu J,Tian Z,Sun Y,Lu C,Liu N,Gao Z,Zhang L,Dong S,Yang F,Zhong X,Xu C,Lu F,Zhang W
Thu Aug 10 00:00:00 EDT 2017
Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy.
PloS one
Park S,Han S,Choi I,Kim B,Park SP,Joe EH,Suh YH
Wed Aug 02 00:00:00 EDT 2017
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys.
Free radical biology & medicine
Gong W,Li J,Chen Z,Huang J,Chen Q,Cai W,Liu P,Huang H
Mon May 01 00:00:00 EDT 2017
Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission.
Redox biology
O'Mealey GB,Berry WL,Plafker SM
Sat Apr 01 00:00:00 EDT 2017
The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1.
Redox biology
Xiao L,Xu X,Zhang F,Wang M,Xu Y,Tang D,Wang J,Qin Y,Liu Y,Tang C,He L,Greka A,Zhou Z,Liu F,Dong Z,Sun L
Sat Apr 01 00:00:00 EDT 2017
KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer.
eLife
Krall EB,Wang B,Munoz DM,Ilic N,Raghavan S,Niederst MJ,Yu K,Ruddy DA,Aguirre AJ,Kim JW,Redig AJ,Gainor JF,Williams JA,Asara JM,Doench JG,Janne PA,Shaw AT,McDonald Iii RE,Engelman JA,Stegmeier F,Schlabach MR,Hahn WC
Wed Feb 01 00:00:00 EST 2017
Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.
Cell death & disease
Ugun-Klusek A,Tatham MH,Elkharaz J,Constantin-Teodosiu D,Lawler K,Mohamed H,Paine SM,Anderson G,John Mayer R,Lowe J,Ellen Billett E,Bedford L
Thu Jan 05 00:00:00 EST 2017
NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury.
Scientific reports
Nlandu-Khodo S,Dissard R,Hasler U,Schäfer M,Pircher H,Jansen-Durr P,Krause KH,Martin PY,de Seigneux S
Wed Dec 07 00:00:00 EST 2016
p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.
Free radical research
Park JS,Oh SY,Lee DH,Lee YS,Sung SH,Ji HW,Lee MJ,Lee YH,Rhee SG,Bae SH
Thu Dec 01 00:00:00 EST 2016
Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.
The Journal of biological chemistry
Mulvaney KM,Matson JP,Siesser PF,Tamir TY,Goldfarb D,Jacobs TM,Cloer EW,Harrison JS,Vaziri C,Cook JG,Major MB
Fri Nov 04 00:00:00 EDT 2016
Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies.
Acta neuropathologica communications
Duleh S,Wang X,Komirenko A,Margeta M
Mon Oct 31 00:00:00 EDT 2016
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis.
Free radical biology & medicine
Lee DH,Han DH,Nam KT,Park JS,Kim SH,Lee M,Kim G,Min BS,Cha BS,Lee YS,Sung SH,Jeong H,Ji HW,Lee MJ,Lee JS,Lee HY,Chun Y,Kim J,Komatsu M,Lee YH,Bae SH
Sat Oct 01 00:00:00 EDT 2016
RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.
Oncogene
Sakurai T,Isogaya K,Sakai S,Morikawa M,Morishita Y,Ehata S,Miyazono K,Koinuma D
Thu Sep 22 00:00:00 EDT 2016
CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2/ARE pathway in glomerular mesangial cells.
Biochemical pharmacology
Gong W,Chen C,Xiong F,Yang Z,Wang Y,Huang J,Liu P,Huang H
Thu Sep 15 00:00:00 EDT 2016
Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer.
Journal of hematology & oncology
Tian Y,Wu K,Liu Q,Han N,Zhang L,Chu Q,Chen Y
Tue Sep 06 00:00:00 EDT 2016
Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues.
Toxicology
Wang S,Chen Y,Kou R,Wang Y,Zeng T,Xie K,Song F
Wed Aug 10 00:00:00 EDT 2016
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Molecules (Basel, Switzerland)
Zhao L,Xu L,Tao X,Han X,Yin L,Qi Y,Peng J
Thu Jul 21 00:00:00 EDT 2016
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Nutrients
Tao X,Sun X,Xu L,Yin L,Han X,Qi Y,Xu Y,Zhao Y,Wang C,Peng J
Fri Jul 08 00:00:00 EDT 2016
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Nature communications
Saito T,Ichimura Y,Taguchi K,Suzuki T,Mizushima T,Takagi K,Hirose Y,Nagahashi M,Iso T,Fukutomi T,Ohishi M,Endo K,Uemura T,Nishito Y,Okuda S,Obata M,Kouno T,Imamura R,Tada Y,Obata R,Yasuda D,Takahashi K,Fujimura T,Pi J,Lee MS,Ueno T,Ohe T,Mashino T,Wakai T,Kojima H,Okabe T,Nagano T,Motohashi H,Waguri S,Soga T,Yamamoto M,Tanaka K,Komatsu M
Mon Jun 27 00:00:00 EDT 2016
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.
Nature communications
Saito T,Ichimura Y,Taguchi K,Suzuki T,Mizushima T,Takagi K,Hirose Y,Nagahashi M,Iso T,Fukutomi T,Ohishi M,Endo K,Uemura T,Nishito Y,Okuda S,Obata M,Kouno T,Imamura R,Tada Y,Obata R,Yasuda D,Takahashi K,Fujimura T,Pi J,Lee MS,Ueno T,Ohe T,Mashino T,Wakai T,Kojima H,Okabe T,Nagano T,Motohashi H,Waguri S,Soga T,Yamamoto M,Tanaka K,Komatsu M
Mon Jun 27 00:00:00 EDT 2016
Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.
PloS one
Probst BL,McCauley L,Trevino I,Wigley WC,Ferguson DA
Wed May 11 00:00:00 EDT 2016
Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis.
Science signaling
Sergin I,Bhattacharya S,Emanuel R,Esen E,Stokes CJ,Evans TD,Arif B,Curci JA,Razani B
Tue Jan 05 00:00:00 EST 2016
Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells.
Journal of cell science
Eino A,Kageyama S,Uemura T,Annoh H,Saito T,Narita I,Waguri S,Komatsu M
Tue Dec 01 00:00:00 EST 2015
Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells.
Journal of cell science
Eino A,Kageyama S,Uemura T,Annoh H,Saito T,Narita I,Waguri S,Komatsu M
Tue Dec 01 00:00:00 EST 2015
PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1.
Biochemical and biophysical research communications
Park JS,Kang DH,Lee DH,Bae SH
Fri Oct 23 00:00:00 EDT 2015
Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity.
Biochemical and biophysical research communications
Park JS,Kang DH,Lee DH,Bae SH
Fri Oct 09 00:00:00 EDT 2015
Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation.
Biochemical and biophysical research communications
Park JS,Kang DH,Lee DH,Bae SH
Fri Sep 25 00:00:00 EDT 2015
p62 prevents carbonyl cyanide m-chlorophenyl hydrazine (CCCP)-induced apoptotic cell death by activating Nrf2.
Biochemical and biophysical research communications
Park JS,Kang DH,Bae SH
Fri Sep 04 00:00:00 EDT 2015
p62 Deficiency Enhances α-Synuclein Pathology in Mice.
Brain pathology (Zurich, Switzerland)
Tanji K,Odagiri S,Miki Y,Maruyama A,Nikaido Y,Mimura J,Mori F,Warabi E,Yanagawa T,Ueno S,Itoh K,Wakabayashi K
Tue Sep 01 00:00:00 EDT 2015
Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Awuh JA,Haug M,Mildenberger J,Marstad A,Do CP,Louet C,Stenvik J,Steigedal M,Damås JK,Halaas Ø,Flo TH
Tue Aug 04 00:00:00 EDT 2015
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Molecular and cellular biology
Bakkar N,Kousari A,Kovalik T,Li Y,Bowser R
Wed Jul 01 00:00:00 EDT 2015
RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1.
Molecular and cellular biology
Bakkar N,Kousari A,Kovalik T,Li Y,Bowser R
Wed Jul 01 00:00:00 EDT 2015
Potent effects of dioscin against liver fibrosis.
Scientific reports
Zhang X,Han X,Yin L,Xu L,Qi Y,Xu Y,Sun H,Lin Y,Liu K,Peng J
Wed Apr 08 00:00:00 EDT 2015
Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells.
American journal of translational research
Huo L,Li CW,Huang TH,Lam YC,Xia W,Tu C,Chang WC,Hsu JL,Lee DF,Nie L,Yamaguchi H,Wang Y,Lang J,Li LY,Chen CH,Mishra L,Hung MC
Wed Jan 28 00:00:00 EST 2015
Potent effects of dioscin against obesity in mice.
Scientific reports
Liu M,Xu L,Yin L,Qi Y,Xu Y,Han X,Zhao Y,Sun H,Yao J,Lin Y,Liu K,Peng J
Thu Jan 22 00:00:00 EST 2015
Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells.
Molecular and cellular endocrinology
Huang K,Chen C,Hao J,Huang J,Wang S,Liu P,Huang H
Mon Jan 05 00:00:00 EST 2015
Spotlite: web application and augmented algorithms for predicting co-complexed proteins from affinity purification--mass spectrometry data.
Journal of proteome research
Goldfarb D,Hast BE,Wang W,Major MB
Fri Dec 05 00:00:00 EST 2014
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Food & function
Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J
Mon Dec 01 00:00:00 EST 2014
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
The Journal of biological chemistry
Kageyama S,Sou YS,Uemura T,Kametaka S,Saito T,Ishimura R,Kouno T,Bedford L,Mayer RJ,Lee MS,Yamamoto M,Waguri S,Tanaka K,Komatsu M
Fri Sep 05 00:00:00 EDT 2014
Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.
The Journal of biological chemistry
Kageyama S,Sou YS,Uemura T,Kametaka S,Saito T,Ishimura R,Kouno T,Bedford L,Mayer RJ,Lee MS,Yamamoto M,Waguri S,Tanaka K,Komatsu M
Fri Sep 05 00:00:00 EDT 2014
SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.
PloS one
Darvekar SR,Elvenes J,Brenne HB,Johansen T,Sjøttem E
Tue Sep 02 00:00:00 EDT 2014
Association of p62/SQSTM1 excess and oral carcinogenesis.
PloS one
Inui T,Chano T,Takikita-Suzuki M,Nishikawa M,Yamamoto G,Okabe H
Fri Jul 18 00:00:00 EDT 2014
Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.
Acta neuropathologica communications
Tanji K,Miki Y,Ozaki T,Maruyama A,Yoshida H,Mimura J,Matsumiya T,Mori F,Imaizumi T,Itoh K,Kakita A,Takahashi H,Wakabayashi K
Sat May 03 00:00:00 EDT 2014
Phosphorylation of serine 349 of p62 in Alzheimer's disease brain.
Acta neuropathologica communications
Tanji K,Miki Y,Ozaki T,Maruyama A,Yoshida H,Mimura J,Matsumiya T,Mori F,Imaizumi T,Itoh K,Kakita A,Takahashi H,Wakabayashi K
Sat May 03 00:00:00 EDT 2014
Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.
Nature communications
Jo C,Gundemir S,Pritchard S,Jin YN,Rahman I,Johnson GV
Tue Mar 25 00:00:00 EDT 2014
Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.
FEBS letters
Ishimura R,Tanaka K,Komatsu M
Mon Mar 03 00:00:00 EST 2014
Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination.
Cancer research
Hast BE,Cloer EW,Goldfarb D,Li H,Siesser PF,Yan F,Walter V,Zheng N,Hayes DN,Major MB
Sat Feb 01 00:00:00 EST 2014
MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).
Hepatology (Baltimore, Md.)
Petrelli A,Perra A,Cora D,Sulas P,Menegon S,Manca C,Migliore C,Kowalik MA,Ledda-Columbano GM,Giordano S,Columbano A
Wed Jan 01 00:00:00 EST 2014
MicroRNA/gene profiling unveils early molecular changes and nuclear factor erythroid related factor 2 (NRF2) activation in a rat model recapitulating human hepatocellular carcinoma (HCC).
Hepatology (Baltimore, Md.)
Petrelli A,Perra A,Cora D,Sulas P,Menegon S,Manca C,Migliore C,Kowalik MA,Ledda-Columbano GM,Giordano S,Columbano A
Wed Jan 01 00:00:00 EST 2014
Keap1 redox-dependent regulation of doxorubicin-induced oxidative stress response in cardiac myoblasts.
Toxicology and applied pharmacology
Nordgren KK,Wallace KB
Wed Jan 01 00:00:00 EST 2014
The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors.
Molecular cancer research : MCR
Yamamoto S,Inoue J,Kawano T,Kozaki K,Omura K,Inazawa J
Wed Jan 01 00:00:00 EST 2014
Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis.
PloS one
Endo H,Niioka M,Kobayashi N,Tanaka M,Watanabe T
Mon Dec 23 00:00:00 EST 2013
Immunohistochemical study of the Nrf2 pathway in colorectal cancer: Nrf2 expression is closely correlated to Keap1 in the tumor and Bach1 in the normal tissue.
Applied immunohistochemistry & molecular morphology : AIMM
Chang LC,Fan CW,Tseng WK,Chen JR,Chein HP,Hwang CC,Hua CC
Sun Dec 01 00:00:00 EST 2013
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Molecular cell
Ichimura Y,Waguri S,Sou YS,Kageyama S,Hasegawa J,Ishimura R,Saito T,Yang Y,Kouno T,Fukutomi T,Hoshii T,Hirao A,Takagi K,Mizushima T,Motohashi H,Lee MS,Yoshimori T,Tanaka K,Yamamoto M,Komatsu M
Thu Sep 12 00:00:00 EDT 2013
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Molecular cell
Ichimura Y,Waguri S,Sou YS,Kageyama S,Hasegawa J,Ishimura R,Saito T,Yang Y,Kouno T,Fukutomi T,Hoshii T,Hirao A,Takagi K,Mizushima T,Motohashi H,Lee MS,Yoshimori T,Tanaka K,Yamamoto M,Komatsu M
Thu Sep 12 00:00:00 EDT 2013
Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin.
PloS one
Jin YN,Yu YV,Gundemir S,Jo C,Cui M,Tieu K,Johnson GV
Tue Aug 27 00:00:00 EDT 2013
Alterations in glutathione levels and apoptotic regulators are associated with acquisition of arsenic trioxide resistance in multiple myeloma.
PloS one
Matulis SM,Morales AA,Yehiayan L,Lee KP,Cai Y,Boise LH
Thu Jun 27 00:00:00 EDT 2013
Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.
Molecular biology of the cell
Volonte D,Liu Z,Musille PM,Stoppani E,Wakabayashi N,Di YP,Lisanti MP,Kensler TW,Galbiati F
Sat Jun 01 00:00:00 EDT 2013
Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence.
Molecular biology of the cell
Volonte D,Liu Z,Musille PM,Stoppani E,Wakabayashi N,Di YP,Lisanti MP,Kensler TW,Galbiati F
Sat Jun 01 00:00:00 EDT 2013
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
Cancer research
Hast BE,Goldfarb D,Mulvaney KM,Hast MA,Siesser PF,Yan F,Hayes DN,Major MB
Mon Apr 01 00:00:00 EDT 2013
Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway.
International journal of cell biology
Kwok SC
Tue Mar 12 00:00:00 EDT 2013
Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.
Journal of neuropathology and experimental neurology
Tanji K,Maruyama A,Odagiri S,Mori F,Itoh K,Kakita A,Takahashi H,Wakabayashi K
Tue Jan 01 00:00:00 EST 2013
Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases.
Journal of neuropathology and experimental neurology
Tanji K,Maruyama A,Odagiri S,Mori F,Itoh K,Kakita A,Takahashi H,Wakabayashi K
Tue Jan 01 00:00:00 EST 2013
Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.
PloS one
Lockwood WW,Wilson IM,Coe BP,Chari R,Pikor LA,Thu KL,Solis LM,Nunez MI,Behrens C,Yee J,English J,Murray N,Tsao MS,Minna JD,Gazdar AF,Wistuba II,MacAulay CE,Lam S,Lam WL
Mon Dec 17 00:00:00 EST 2012
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Cancer research
Leinonen HM,Ruotsalainen AK,Määttä AM,Laitinen HM,Kuosmanen SM,Kansanen E,Pikkarainen JT,Lappalainen JP,Samaranayake H,Lesch HP,Kaikkonen MU,Ylä-Herttuala S,Levonen AL
Sat Dec 01 00:00:00 EST 2012
Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle.
Biochimica et biophysica acta
Miller CJ,Gounder SS,Kannan S,Goutam K,Muthusamy VR,Firpo MA,Symons JD,Paine R,Hoidal JR,Rajasekaran NS
Fri Jun 01 00:00:00 EDT 2012
Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression.
Biochemical and biophysical research communications
Thanan R,Ma N,Iijima K,Abe Y,Koike T,Shimosegawa T,Pinlaor S,Hiraku Y,Oikawa S,Murata M,Kawanishi S
Fri May 04 00:00:00 EDT 2012
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
The Journal of biological chemistry
Camp ND,James RG,Dawson DW,Yan F,Davison JM,Houck SA,Tang X,Zheng N,Major MB,Moon RT
Fri Feb 24 00:00:00 EST 2012
Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles.
Breast cancer research and treatment
Agyeman AS,Chaerkady R,Shaw PG,Davidson NE,Visvanathan K,Pandey A,Kensler TW
Wed Feb 01 00:00:00 EST 2012
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
EMBO reports
Kwon J,Han E,Bui CB,Shin W,Lee J,Lee S,Choi YB,Lee AH,Lee KH,Park C,Obin MS,Park SK,Seo YJ,Oh GT,Lee HW,Shin J
Wed Feb 01 00:00:00 EST 2012
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
EMBO reports
Kwon J,Han E,Bui CB,Shin W,Lee J,Lee S,Choi YB,Lee AH,Lee KH,Park C,Obin MS,Park SK,Seo YJ,Oh GT,Lee HW,Shin J
Wed Feb 01 00:00:00 EST 2012
Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium.
Free radical biology & medicine
Muthusamy VR,Kannan S,Sadhaasivam K,Gounder SS,Davidson CJ,Boeheme C,Hoidal JR,Wang L,Rajasekaran NS
Sun Jan 15 00:00:00 EST 2012
Rat H9c2 cardiac myocytes are sensitive to arsenite due to a modest activation of transcription factor Nrf2.
Archives of toxicology
Sumi D,Sasaki T,Miyataka H,Himeno S
Thu Dec 01 00:00:00 EST 2011
Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe.
Biochemical and biophysical research communications
Bui CB,Shin J
Fri Aug 26 00:00:00 EDT 2011
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
The Journal of cell biology
Inami Y,Waguri S,Sakamoto A,Kouno T,Nakada K,Hino O,Watanabe S,Ando J,Iwadate M,Yamamoto M,Lee MS,Tanaka K,Komatsu M
Mon Apr 18 00:00:00 EDT 2011
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells.
The Journal of cell biology
Inami Y,Waguri S,Sakamoto A,Kouno T,Nakada K,Hino O,Watanabe S,Ando J,Iwadate M,Yamamoto M,Lee MS,Tanaka K,Komatsu M
Mon Apr 18 00:00:00 EDT 2011
Autophagy-deficient mice develop multiple liver tumors.
Genes & development
Takamura A,Komatsu M,Hara T,Sakamoto A,Kishi C,Waguri S,Eishi Y,Hino O,Tanaka K,Mizushima N
Fri Apr 15 00:00:00 EDT 2011
Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.
Antioxidants & redox signaling
Rajasekaran NS,Varadharaj S,Khanderao GD,Davidson CJ,Kannan S,Firpo MA,Zweier JL,Benjamin IJ
Tue Mar 15 00:00:00 EDT 2011
Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.
Antioxidants & redox signaling
Rajasekaran NS,Varadharaj S,Khanderao GD,Davidson CJ,Kannan S,Firpo MA,Zweier JL,Benjamin IJ
Tue Mar 15 00:00:00 EDT 2011
Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features.
Clinical cancer research : an official journal of the American Association for Cancer Research
Solis LM,Behrens C,Dong W,Suraokar M,Ozburn NC,Moran CA,Corvalan AH,Biswal S,Swisher SG,Bekele BN,Minna JD,Stewart DJ,Wistuba II
Thu Jul 15 00:00:00 EDT 2010
Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features.
Clinical cancer research : an official journal of the American Association for Cancer Research
Solis LM,Behrens C,Dong W,Suraokar M,Ozburn NC,Moran CA,Corvalan AH,Biswal S,Swisher SG,Bekele BN,Minna JD,Stewart DJ,Wistuba II
Thu Jul 15 00:00:00 EDT 2010
CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.
The Journal of biological chemistry
Kang HJ,Hong YB,Kim HJ,Bae I
Fri Jul 09 00:00:00 EDT 2010
CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.
The Journal of biological chemistry
Kang HJ,Hong YB,Kim HJ,Bae I
Fri Jul 09 00:00:00 EDT 2010
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Nature cell biology
Komatsu M,Kurokawa H,Waguri S,Taguchi K,Kobayashi A,Ichimura Y,Sou YS,Ueno I,Sakamoto A,Tong KI,Kim M,Nishito Y,Iemura S,Natsume T,Ueno T,Kominami E,Motohashi H,Tanaka K,Yamamoto M
Mon Mar 01 00:00:00 EST 2010
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Nature cell biology
Komatsu M,Kurokawa H,Waguri S,Taguchi K,Kobayashi A,Ichimura Y,Sou YS,Ueno I,Sakamoto A,Tong KI,Kim M,Nishito Y,Iemura S,Natsume T,Ueno T,Kominami E,Motohashi H,Tanaka K,Yamamoto M
Mon Mar 01 00:00:00 EST 2010
KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta.
Molecular cell
Lee DF,Kuo HP,Liu M,Chou CK,Xia W,Du Y,Shen J,Chen CT,Huo L,Hsu MC,Li CW,Ding Q,Liao TL,Lai CC,Lin AC,Chang YH,Tsai SF,Li LY,Hung MC
Fri Oct 09 00:00:00 EDT 2009
Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis.
The Journal of biological chemistry
Morales AA,Gutman D,Cejas PJ,Lee KP,Boise LH
Fri May 08 00:00:00 EDT 2009
Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.
Circulation research
Dai G,Vaughn S,Zhang Y,Wang ET,Garcia-Cardena G,Gimbrone MA
Fri Sep 28 00:00:00 EDT 2007
Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/Akt-dependent activation of Nrf2.
Circulation research
Dai G,Vaughn S,Zhang Y,Wang ET,Garcia-Cardena G,Gimbrone MA
Fri Sep 28 00:00:00 EDT 2007
scaffold/adaptor protein
