Proteintech

KIAA1199 Polyclonal Antibody

Product Image Gallery

KIAA1199 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of HepG2 cells, using CEMIP antibody 21129-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

KIAA1199 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded mouse testis tissue slide using 21129-1-AP (KIAA1199 Antibody) at dilution of 1:200 (under 40x lens).

KIAA1199 Antibody in Western Blot (WB) — SGC-7901 cells were subjected to SDS PAGE followed by western blot with 21129-1-AP (KIAA1199 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

Product Details

21129-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	View 7 publications 7 publications
Immunohistochemistry (IHC)	-	View 6 publications 6 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	1:10-1:100	View 2 publications 2 publications
Immunoprecipitation (IP)	Assay-dependent	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse, Non-human primate
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	KIAA1199 Fusion Protein Ag15527 (31-386 aa encoded by BC020256) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.3 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: TVAAGCPDQ SPELQPWNPG HDQDHHVHIG QGKTLLLTSS ATVYSIHISE GGKLVIKDHD EPIVLRTRHI LIDNGGELHA GSALCPFQGN FTIILYGRAD EGIQPDPYYG LKYIGVGKGG ALELHGQKKL SWTFLNKTLH PGGMAEGGYF FERSWGHRGV IVHVIDPKSG TVIHSDRFDT YRSKKESERL VQYLNAVPDG RILSVAVNDE GSRNLDDMAR KAMTKLGSKH FLHLGFRHPW SFLTVKGNPS SSVEDHIEYH GHRGSAAARV FKLFQTEHGE YFNVSLSSEW VQDVEWTEWF DHDKVSQTKG GEKISDLWKA HPGKICNRPI DIQATTMDGV NLSTEVVYKK GQDYRFA (31-386 aa encoded by BC020256)

Target Information

The function of this protein remains unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

KIAA1199 overexpression is associated with abnormal expression of EMT markers and is a novel independent prognostic biomarker for hepatocellular carcinoma.

OncoTargets and therapy

Jiang Z,Zhai X,Shi B,Luo D,Jin B

Wed Mar 30 00:00:00 EDT 2022

KIAA1199 overexpression is associated with abnormal expression of EMT markers and is a novel independent prognostic biomarker for hepatocellular carcinoma.

OncoTargets and therapy

Jiang Z,Zhai X,Shi B,Luo D,Jin B

Wed Mar 30 00:00:00 EDT 2022

KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway.

Oncogene

Zhao L,Zhang D,Shen Q,Jin M,Lin Z,Ma H,Huang S,Zhou P,Wu G,Zhang T

Fri Feb 01 00:00:00 EST 2019

KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway.

Oncogene

Zhao L,Zhang D,Shen Q,Jin M,Lin Z,Ma H,Huang S,Zhou P,Wu G,Zhang T

Fri Feb 01 00:00:00 EST 2019

KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway.

Oncogene

Zhao L,Zhang D,Shen Q,Jin M,Lin Z,Ma H,Huang S,Zhou P,Wu G,Zhang T

Fri Feb 01 00:00:00 EST 2019

Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets.

Theranostics

Hartmans E,Orian-Rousseau V,Matzke-Ogi A,Karrenbeld A,de Groot DJ,de Jong S,van Dam GM,Fehrmann RS,Nagengast WB

Mon Oct 23 00:00:00 EDT 2017

KIAA1199/CEMIP/HYBID overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Koga A,Sato N,Kohi S,Yabuki K,Cheng XB,Hisaoka M,Hirata K

Wed Aug 09 00:00:00 EDT 2017

Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model.

Scientific reports

Higuchi Y,Nishida Y,Kozawa E,Zhuo L,Arai E,Hamada S,Morita D,Ikuta K,Kimata K,Ushida T,Ishiguro N

Tue Aug 01 00:00:00 EDT 2017

Down-regulation of KIAA1199/CEMIP by miR-216a suppresses tumor invasion and metastasis in colorectal cancer.

International journal of cancer

Zhang D,Zhao L,Shen Q,Lv Q,Jin M,Ma H,Nie X,Zheng X,Huang S,Zhou P,Wu G,Zhang T

Mon May 15 00:00:00 EDT 2017

Down-regulation of KIAA1199/CEMIP by miR-216a suppresses tumor invasion and metastasis in colorectal cancer.

International journal of cancer

Zhang D,Zhao L,Shen Q,Lv Q,Jin M,Ma H,Nie X,Zheng X,Huang S,Zhou P,Wu G,Zhang T

Mon May 15 00:00:00 EDT 2017

KIAA1199 promotes migration and invasion by Wnt/β-catenin pathway and MMPs mediated EMT progression and serves as a poor prognosis marker in gastric cancer.

PloS one

Jia S,Qu T,Wang X,Feng M,Yang Y,Feng X,Ma R,Li W,Hu Y,Feng Y,Ji K,Li Z,Jiang W,Ji J

Thu Apr 27 00:00:00 EDT 2017

KIAA1199 is induced by inflammation and enhances malignant phenotype in pancreatic cancer.

Oncotarget

Kohi S,Sato N,Koga A,Matayoshi N,Hirata K

Tue Mar 07 00:00:00 EST 2017

Distinct Expression Pattern of a Deafness Gene, KIAA1199, in a Primate Cochlea.

BioMed research international

Hosoya M,Fujioka M,Okano H,Ogawa K

Tue Feb 14 00:00:00 EST 2017

Cochlear Cell Modeling Using Disease-Specific iPSCs Unveils a Degenerative Phenotype and Suggests Treatments for Congenital Progressive Hearing Loss.

Cell reports

Hosoya M,Fujioka M,Sone T,Okamoto S,Akamatsu W,Ukai H,Ueda HR,Ogawa K,Matsunaga T,Okano H

Tue Jan 03 00:00:00 EST 2017

Crohn's Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan Fragments.

Cellular and molecular gastroenterology and hepatology

Soroosh A,Albeiroti S,West GA,Willard B,Fiocchi C,de la Motte CA

Sun May 01 00:00:00 EDT 2016

Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness.

BMC cancer

Jami MS,Hou J,Liu M,Varney ML,Hassan H,Dong J,Geng L,Wang J,Yu F,Huang X,Peng H,Fu K,Li Y,Singh RK,Ding SJ

Sat Mar 15 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: cell migration inducing protein, hyaluronan binding; Cell migration-inducing and hyaluronan-binding protein; colon cancer secreted protein 1; hyaluronan-binding protein involved in hyaluronan depolymerization; Protein 12H19.01.T7; protein KIAA1199

Gene Aliases: 12H19.01.T7; 6330404C01Rik; 9930013L23Rik; AY007814; CCSP1; CEMIP; HYBID; KIAA1199; RGD1305254; TMEM2L

UniProt ID: (Human) Q8WUJ3, (Mouse) Q8BI06

Entrez Gene ID: (Human) 57214, (Mouse) 80982, (Rat) 308797

Function(s)

sensory perception of sound positive regulation of peptidyl-threonine phosphorylation hyaluronan biosynthetic process hyaluronan catabolic process positive regulation of cell migration positive regulation of release of sequestered calcium ion into cytosol positive regulation of protein targeting to membrane positive regulation of protein kinase C activity metabolic process

Process(es)

hyalurononglucosaminidase activity protein binding hyaluronic acid binding clathrin heavy chain binding ER retention sequence binding hydrolase activity hydrolase activity, acting on glycosyl bonds