Proteintech

KIAA1199 Polyclonal Antibody

KIAA1199 Antibody in Immunocytochemistry (ICC/IF)

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KIAA1199 Antibody (21129-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using CEMIP antibody 21129-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

KIAA1199 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

21129-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 27 publications 27 publications

Immunohistochemistry (IHC)

View 23 publications 23 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 7 publications 7 publications

Immunoprecipitation (IP)

Assay-dependent

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KIAA1199 Fusion Protein Ag15527 (31-386 aa encoded by BC020256)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TVAAGCPDQ SPELQPWNPG HDQDHHVHIG QGKTLLLTSS ATVYSIHISE GGKLVIKDHD EPIVLRTRHI LIDNGGELHA GSALCPFQGN FTIILYGRAD EGIQPDPYYG LKYIGVGKGG ALELHGQKKL SWTFLNKTLH PGGMAEGGYF FERSWGHRGV IVHVIDPKSG TVIHSDRFDT YRSKKESERL VQYLNAVPDG RILSVAVNDE GSRNLDDMAR KAMTKLGSKH FLHLGFRHPW SFLTVKGNPS SSVEDHIEYH GHRGSAAARV FKLFQTEHGE YFNVSLSSEW VQDVEWTEWF DHDKVSQTKG GEKISDLWKA HPGKICNRPI DIQATTMDGV NLSTEVVYKK GQDYRFA (31-386 aa encoded by BC020256)

Target Information

The function of this protein remains unknown.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hyaluronan in articular cartilage: Analysis of hip osteoarthritis and osteonecrosis of femoral head.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Zhang J,Nishida Y,Koike H,Ito K,Zhuo L,Nishida K,Kimata K,Ikuta K,Sakai T,Urakawa H,Seki T,Imagama S

Wed Feb 01 00:00:00 UTC 2023

KIAA1199 promotes oxaliplatin resistance and epithelial mesenchymal transition of colorectal cancer via protein O-GlcNAcylation.

Translational oncology

Hua Q,Lu Y,Wang D,Da J,Peng W,Sun G,Gu K,Wang H,Zhu Y

Wed Feb 01 00:00:00 UTC 2023

KIAA1199 promotes oxaliplatin resistance and epithelial mesenchymal transition of colorectal cancer via protein O-GlcNAcylation.

Translational oncology

Hua Q,Lu Y,Wang D,Da J,Peng W,Sun G,Gu K,Wang H,Zhu Y

Wed Feb 01 00:00:00 UTC 2023

Downregulation of CEMIP enhances radiosensitivity by promoting DNA damage and apoptosis in colorectal cancer.

Medical oncology (Northwood, London, England)

Weng J,Zhang Y,Liang W,Xie Y,Wang K,Xu Q,Ding Y,Li Y

Fri Jan 06 00:00:00 UTC 2023

CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.

Cell death & disease

Xu G,Zhao L,Hua Q,Wang L,Liu H,Lin Z,Jin M,Wang J,Zhou P,Yang K,Wu G,Yu D,Zhang D,Zhang T

Mon Feb 27 00:00:00 UTC 2023

CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.

Cell death & disease

Xu G,Zhao L,Hua Q,Wang L,Liu H,Lin Z,Jin M,Wang J,Zhou P,Yang K,Wu G,Yu D,Zhang D,Zhang T

Mon Feb 27 00:00:00 UTC 2023

CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.

Cell death & disease

Xu G,Zhao L,Hua Q,Wang L,Liu H,Lin Z,Jin M,Wang J,Zhou P,Yang K,Wu G,Yu D,Zhang D,Zhang T

Mon Feb 27 00:00:00 UTC 2023

CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1, promotes colorectal cancer metastasis via activating CDC42/MAPK pathway.

Cell death & disease

Xu G,Zhao L,Hua Q,Wang L,Liu H,Lin Z,Jin M,Wang J,Zhou P,Yang K,Wu G,Yu D,Zhang D,Zhang T

Mon Feb 27 00:00:00 UTC 2023

KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration.

Nature communications

Chen L,Shi K,Ditzel N,Qiu W,Figeac F,Nielsen LHD,Tencerova M,Kowal JM,Ding M,Andreasen CM,Andersen TL,Kassem M

Mon Apr 10 00:00:00 UTC 2023

A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage.

Matrix biology : journal of the International Society for Matrix Biology

Yamamoto K,Scavenius C,Meschis MM,Gremida AME,Mogensen EH,Thøgersen IB,Bonelli S,Scilabra SD,Jensen A,Santamaria S,Ahnström J,Bou-Gharios G,Enghild JJ,Nagase H

Thu Sep 01 00:00:00 UTC 2022

A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage.

Matrix biology : journal of the International Society for Matrix Biology

Yamamoto K,Scavenius C,Meschis MM,Gremida AME,Mogensen EH,Thøgersen IB,Bonelli S,Scilabra SD,Jensen A,Santamaria S,Ahnström J,Bou-Gharios G,Enghild JJ,Nagase H

Thu Sep 01 00:00:00 UTC 2022

A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage.

Matrix biology : journal of the International Society for Matrix Biology

Yamamoto K,Scavenius C,Meschis MM,Gremida AME,Mogensen EH,Thøgersen IB,Bonelli S,Scilabra SD,Jensen A,Santamaria S,Ahnström J,Bou-Gharios G,Enghild JJ,Nagase H

Thu Sep 01 00:00:00 UTC 2022

A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage.

Matrix biology : journal of the International Society for Matrix Biology

Yamamoto K,Scavenius C,Meschis MM,Gremida AME,Mogensen EH,Thøgersen IB,Bonelli S,Scilabra SD,Jensen A,Santamaria S,Ahnström J,Bou-Gharios G,Enghild JJ,Nagase H

Thu Sep 01 00:00:00 UTC 2022

Expression and regulation of recently discovered hyaluronidases, HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage.

Scientific reports

Shiozawa J,de Vega S,Yoshinaga C,Ji X,Negishi Y,Momoeda M,Nakamura T,Yoshida H,Kaneko H,Ishijima M,Okada Y

Fri Oct 14 00:00:00 UTC 2022

Expression and regulation of recently discovered hyaluronidases, HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage.

Scientific reports

Shiozawa J,de Vega S,Yoshinaga C,Ji X,Negishi Y,Momoeda M,Nakamura T,Yoshida H,Kaneko H,Ishijima M,Okada Y

Fri Oct 14 00:00:00 UTC 2022

KIAA1199 Correlates With Tumor Microenvironment and Immune Infiltration in Lung Adenocarcinoma as a Potential Prognostic Biomarker.

Pathology oncology research : POR

Shen X,Mo X,Tan W,Mo X,Li L,Yu F,He J,Deng Z,Xing S,Chen Z,Yang J

Thu Dec 01 00:00:00 UTC 2022

CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway.

Frontiers in oncology

Cheng J,Zhang Y,Wan R,Zhou J,Wu X,Fan Q,He J,Tan W,Deng Y

Sat Aug 13 00:00:00 UTC 2022

CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway.

Frontiers in oncology

Cheng J,Zhang Y,Wan R,Zhou J,Wu X,Fan Q,He J,Tan W,Deng Y

Sat Aug 13 00:00:00 UTC 2022

CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway.

Frontiers in oncology

Cheng J,Zhang Y,Wan R,Zhou J,Wu X,Fan Q,He J,Tan W,Deng Y

Sat Aug 13 00:00:00 UTC 2022

CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway.

Frontiers in oncology

Cheng J,Zhang Y,Wan R,Zhou J,Wu X,Fan Q,He J,Tan W,Deng Y

Sat Aug 13 00:00:00 UTC 2022

Single-cell analysis of human basal cell carcinoma reveals novel regulators of tumor growth and the tumor microenvironment.

Science advances

Guerrero-Juarez CF,Lee GH,Liu Y,Wang S,Karikomi M,Sha Y,Chow RY,Nguyen TTL,Iglesias VS,Aasi S,Drummond ML,Nie Q,Sarin K,Atwood SX

Fri Jun 10 00:00:00 UTC 2022

Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.

Translational oncology

Liu X,Li N,Zhang C,Wu X,Zhang S,Dong G,Liu G

Sun May 01 00:00:00 UTC 2022

Identification of metastasis-associated exoDEPs in colorectal cancer using label-free proteomics.

Translational oncology

Liu X,Li N,Zhang C,Wu X,Zhang S,Dong G,Liu G

Sun May 01 00:00:00 UTC 2022

Altered regulation of DPF3, a member of the SWI/SNF complexes, underlies the 14q24 renal cancer susceptibility locus.

American journal of human genetics

Colli LM,Jessop L,Myers TA,Camp SY,Machiela MJ,Choi J,Cunha R,Onabajo O,Mills GC,Schmid V,Brodie SA,Delattre O,Mole DR,Purdue MP,Yu K,Brown KM,Chanock SJ

Thu Sep 02 00:00:00 UTC 2021

Lenvatinib induces anticancer activity in gallbladder cancer by targeting AKT.

Journal of Cancer

Ye J,Qi L,Liang J,Zong K,Liu W,Li R,Feng R,Zhai W

Tue May 18 00:00:00 UTC 2021

Hypoxia increases KIAA1199/CEMIP expression and enhances cell migration in pancreatic cancer.

Scientific reports

Oba T,Sato N,Adachi Y,Amaike T,Kudo Y,Koga A,Kohi S,Hirata K

Tue Sep 14 00:00:00 UTC 2021

Hypoxia increases KIAA1199/CEMIP expression and enhances cell migration in pancreatic cancer.

Scientific reports

Oba T,Sato N,Adachi Y,Amaike T,Kudo Y,Koga A,Kohi S,Hirata K

Tue Sep 14 00:00:00 UTC 2021

Efficacy of hyaluronic acid on intervertebral disc inflammation: An in vitro study using notochordal cell lines and human disc cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Yamamoto T,Suzuki S,Fujii T,Mima Y,Watanabe K,Matsumoto M,Nakamura M,Fujita N

Fri Oct 01 00:00:00 UTC 2021

Efficacy of hyaluronic acid on intervertebral disc inflammation: An in vitro study using notochordal cell lines and human disc cells.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Yamamoto T,Suzuki S,Fujii T,Mima Y,Watanabe K,Matsumoto M,Nakamura M,Fujita N

Fri Oct 01 00:00:00 UTC 2021

Deletion of Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization (HYBID) Results in Attenuation of Osteoarthritis in Mice.

The American journal of pathology

Momoeda M,de Vega S,Kaneko H,Yoshinaga C,Shimoda M,Nakamura T,Endo Y,Yoshida H,Kaneko K,Ishijima M,Okada Y

Mon Nov 01 00:00:00 UTC 2021

HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth.

Brain research

Tsuji S,Nakamura S,Yamada T,de Vega S,Okada Y,Inoue S,Shimazawa M,Hara H

Sun Aug 01 00:00:00 UTC 2021

HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth.

Brain research

Tsuji S,Nakamura S,Yamada T,de Vega S,Okada Y,Inoue S,Shimazawa M,Hara H

Sun Aug 01 00:00:00 UTC 2021

Overexpression of KIAA1199, a novel strong hyaluronidase, is a poor prognostic factor in patients with osteosarcoma.

Journal of orthopaedic surgery and research

Ito K,Nishida Y,Ikuta K,Urakawa H,Koike H,Sakai T,Zhang J,Shimoyama Y,Imagama S

Wed Jul 07 00:00:00 UTC 2021

Comprehensive histological investigation of age-related changes in dermal extracellular matrix and muscle fibers in the upper lip vermilion.

International journal of cosmetic science

Gomi T,Imamura T

Sat Aug 01 00:00:00 UTC 2020

Serum KIAA1199 is an advanced-stage prognostic biomarker and metastatic oncogene in cholangiocarcinoma.

Aging

Zhai X,Wang W,Ma Y,Zeng Y,Dou D,Fan H,Song J,Yu X,Xin D,Du G,Jiang Z,Zhang H,Zhang X,Jin B

Tue Nov 10 00:00:00 UTC 2020

Serum KIAA1199 is an advanced-stage prognostic biomarker and metastatic oncogene in cholangiocarcinoma.

Aging

Zhai X,Wang W,Ma Y,Zeng Y,Dou D,Fan H,Song J,Yu X,Xin D,Du G,Jiang Z,Zhang H,Zhang X,Jin B

Tue Nov 10 00:00:00 UTC 2020

Forced expression of KIAA1199, a novel hyaluronidase, inhibits tumorigenicity of low-grade chondrosarcoma.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Koike H,Nishida Y,Shinomura T,Zhuo L,Hamada S,Ikuta K,Ito K,Kimata K,Ushida T,Ishiguro N

Tue Sep 01 00:00:00 UTC 2020

Co-expression of KIAA1199 and hypoxia-inducible factor 1α is a biomarker for an unfavorable prognosis in hepatocellular carcinoma.

Medicine

Wang D,Lu S,Zhang X,Huang L,Zhao H

Fri Dec 11 00:00:00 UTC 2020

Co-expression of KIAA1199 and hypoxia-inducible factor 1α is a biomarker for an unfavorable prognosis in hepatocellular carcinoma.

Medicine

Wang D,Lu S,Zhang X,Huang L,Zhao H

Fri Dec 11 00:00:00 UTC 2020

A novel metastatic promoter CEMIP and its downstream molecular targets and signaling pathway of cellular migration and invasion in SCLC cells based on proteome analysis.

Journal of cancer research and clinical oncology

Li L,Pan Y,Mo X,Wei T,Song J,Luo M,Huang G,Teng C,Liang K,Mao N,Yang J

Thu Oct 01 00:00:00 UTC 2020

Implication of HYBID (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization) in Hyaluronan Degradation by Synovial Fibroblasts in Patients with Knee Osteoarthritis.

The American journal of pathology

Shiozawa J,de Vega S,Cilek MZ,Yoshinaga C,Nakamura T,Kasamatsu S,Yoshida H,Kaneko H,Ishijima M,Kaneko K,Okada Y

Fri May 01 00:00:00 UTC 2020

Implication of HYBID (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization) in Hyaluronan Degradation by Synovial Fibroblasts in Patients with Knee Osteoarthritis.

The American journal of pathology

Shiozawa J,de Vega S,Cilek MZ,Yoshinaga C,Nakamura T,Kasamatsu S,Yoshida H,Kaneko H,Ishijima M,Kaneko K,Okada Y

Fri May 01 00:00:00 UTC 2020

Implication of HYBID (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization) in Hyaluronan Degradation by Synovial Fibroblasts in Patients with Knee Osteoarthritis.

The American journal of pathology

Shiozawa J,de Vega S,Cilek MZ,Yoshinaga C,Nakamura T,Kasamatsu S,Yoshida H,Kaneko H,Ishijima M,Kaneko K,Okada Y

Fri May 01 00:00:00 UTC 2020

KIAA1199 promotes metastasis of colorectal cancer cells via microtubule destabilization regulated by a PP2A/stathmin pathway.

Oncogene