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Product Details
21856-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 3 publications 3 publications |
Immunoprecipitation (IP) |
Assay-dependent | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KIDINS220 Fusion Protein Ag16448 (1374-1672 aa encoded by BC130610) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.4 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: LDPITEEDE KSDQSGSKLL PGKKSSERSS LFQTDLKLKG SGLRYQKLPS DEDESGTEES DNTPLLKDDK DRKAEGKVER VPKSPEHSAE PIRTFIKAKE YLSDALLDKK DSSDSGVRSS ESSPNHSLHN EVADDSQLEK ANLIELEDDS HSGKRGIPHS LSGLQDPIIA RMSICSEDKK SPSECSLIAS SPEENWPACQ KAYNLNRTPS TVTLNNNSAP ANRANQNFDE MEGIRETSQV ILRPSSSPNP TTIQNENLKS MTHKRSQRSS YTRLSKDPPE LHAAASSEST GFGEERESIL (1374-1672 aa encoded by BC130610)
Target Information
This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ankyrin repeat-rich membrane spanning; Ankyrin repeat-rich membrane-spanning protein; Kinase D-interacting substrate of 220 kDa; kinase D-interacting substrate, 220kDa; MGC163482; truncated KIDINS220
Gene Aliases: ARMS; KIAA1250; KIDINS220
UniProt ID: (Human) Q9ULH0
Entrez Gene ID: (Human) 57498
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