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Bethyl Laboratories
KIF1B Polyclonal Antibody
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FIGURE: 1 / 1
KIF1B Antibody (A301-055A) in WB
Detection of human and mouse KIF1B by western blot (h&m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), HEK293T (T; 50 µg) and mouse NIH 3T3 (M; 50 µg) cells. Antibodies: Affinity purified rabbit anti-KIF1B antibody (Product # A301-055A) used for WB at 0.1 µg/mL (A) and 1 µg/mL (B) and used for IP at 3 µg/mg lysate. KIF1B was also immunoprecipitated by rabbit anti-KIF1B antibody A301-056A, which recognizes a downstream epitope. Detection: Chemiluminescence with exp... View More
Product Details
A301-055A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1575 and 1625 of human kinesin family member 1B.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF1B is a member of the KIF1/Unc104 family of kinesin-like proteins that are involved in the transport of mitochondria or synaptic vesicles in axons. KIF1B is an amino-terminal-type motor protein that is ubiquitously expressed, with the most abundant levels in differentiated nerve cells. The human KIF1B gene maps to chromosome 1p36. 2. Defects in axonal transport due to mutations at the KIF1B gene can underlie the human peripheral neuropathy phenotype. The mouse KIF1B gene generates an alternatively spliced transcript, which produces two isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Charcot-Marie-Tooth neuropathy type II; kinesin heavy chain member 1B; kinesin related protein; kinesin superfamily protein KIF1B; Kinesin-like protein KIF1B; Klp; N-3 kinesin; unnamed protein product
Gene Aliases: A530096N05Rik; AI448212; AI506502; CMT2; CMT2A; CMT2A1; D4Mil1e; HMSNII; KIAA0591; KIAA1448; KIF1B; KIF1Bp130; KIF1Bp204; KLP; NBLST1
UniProt ID: (Human) O60333, (Mouse) Q60575
Entrez Gene ID: (Human) 23095, (Mouse) 16561
apoptotic process
microtubule-based movement
neuron-neuron synaptic transmission
neuromuscular synaptic transmission
transport along microtubule
vesicle-mediated transport
mitochondrion transport along microtubule
anterograde synaptic vesicle transport
apoptotic process involved in development
retrograde neuronal dense core vesicle transport
anterograde axonal transport
embryo development
cytoskeleton-dependent intracellular transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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