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Invitrogen
KIF1B Polyclonal Antibody
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FIGURE: 1 / 1
KIF1B Antibody (PA5-93117) in WB
Western blot analysis of KIF1B in extracts of SKOV3 cells. Samples were incubated with KIF1B Polyclonal antibody (Product # PA5-93117) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-93117
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1501-1770 of human KIF1B (NP_0558892)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Amount
38 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SQISTTTFES AITPSESSGY DSGDIESLVD REKELATKCL QLLTHTFNRE FSQVHGSVSD CKLSDISPIG RDPSESSFSS ATLTPSSTCP SLVDSRSNSL DQKTPEANSR ASSPCPEFEQ FQIVPAVETP YLARAGKNEF LNLVPDIEEI RPSSVVSKKG YLHFKEPLYS NWAKHFVVVR RPYVFIYNSD KDPVERGIIN LSTAQVEYSE DQQAMVKTPN TFAVCTKHRG VLLQALNDKD MNDWLYAFNP LLAGTIRSKL SRRCPSQSKY; Positive Samples: SKOV3; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Mitochondrion, cytoskeleton
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. KIF1B is a member of the KIF1/Unc104 family of kinesin-like proteins that are involved in the transport of mitochondria or synaptic vesicles in axons. KIF1B is an amino-terminal-type motor protein that is ubiquitously expressed, with the most abundant levels in differentiated nerve cells. The human KIF1B gene maps to chromosome 1p36. 2. Defects in axonal transport due to mutations at the KIF1B gene can underlie the human peripheral neuropathy phenotype. The mouse KIF1B gene generates an alternatively spliced transcript, which produces two isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Charcot-Marie-Tooth neuropathy type II; kinesin heavy chain member 1B; kinesin related protein; kinesin superfamily protein KIF1B; kinesin-family protein KIF1Bbeta3; Kinesin-like protein KIF1B; Klp; N-3 kinesin; unnamed protein product
Gene Aliases: A530096N05Rik; AI448212; AI506502; CMT2; CMT2A; CMT2A1; D4Mil1e; HMSNII; KIAA0591; KIAA1448; KIF1B; KIF1Bp130; KIF1Bp204; KLP; NBLST1
UniProt ID: (Human) O60333, (Rat) O88658, (Mouse) Q60575
Entrez Gene ID: (Human) 23095, (Rat) 117548, (Mouse) 16561
nucleotide binding
motor activity
microtubule motor activity
protein binding
ATP binding
microtubule binding
ATP-dependent microtubule motor activity, plus-end-directed
isomerase activity
ATPase activity
kinesin binding
phosphogluconate dehydrogenase (decarboxylating) activity
protein heterodimerization activity
NADP binding
microtubule binding motor protein
apoptotic process
microtubule-based movement
neuron-neuron synaptic transmission
neuromuscular synaptic transmission
transport along microtubule
vesicle-mediated transport
mitochondrion transport along microtubule
anterograde synaptic vesicle transport
apoptotic process involved in development
retrograde neuronal dense core vesicle transport
pentose-phosphate shunt
anterograde axonal transport
metabolic process
cytoskeleton-dependent intracellular transport
oxidation-reduction process
embryo development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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