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Proteintech
KIF2A Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-27218
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KIF2A fusion protein Ag25692
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VDPTAAGDV RPIMHHPPNQ IDDLETQWGV GSSPQRDDLK LLCEQNEEEV SPQLFTFHEA VSQMVEMEEQ VVEDHRAVFQ ESIRWLEDEK ALLEMTEEVD YDVDSYATQL EAILEQKIDI LTELRDKVKS FRAALQEEEQ ASKQINPKRP RAL
Target Information
KIF2A, a gene encoding the kinesin family member 2A protein, plays a pivotal role in neuronal development and function. This gene is part of the kinesin-13 subfamily, characterized by its unique ability to depolymerize microtubules, which are essential components of the cytoskeleton responsible for maintaining cell shape, enabling motility, and facilitating intracellular transport. KIF2A is particularly significant in neural settings, where it regulates microtubule dynamics crucial for neuronal migration and dendritic development. Dysfunctional KIF2A, due to mutations, has been linked to early-onset neurodegenerative diseases such as progressive microcephaly and mental disabilities due to impaired microtubule regulation, reflecting its foundational role in correct brain development and architecture. Additionally, KIF2A is involved in spindle assembly and chromosome segregation during cell division, further cementing its importance in both neurodevelopment and general cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hK2; kinesin heavy chain member 2; kinesin heavy chain member 2A; Kinesin, heavy chain, 2; Kinesin-2; Kinesin-like protein KIF2A
Gene Aliases: C530030B14Rik; CDCBM3; HK2; KIF2; KIF2A; KNS2; M-kinesin
UniProt ID: (Human) O00139, (Mouse) P28740
Entrez Gene ID: (Human) 3796, (Mouse) 16563
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
mitotic spindle organization
sister chromatid cohesion
nervous system development
antigen processing and presentation of exogenous peptide antigen via MHC class II
cell differentiation
cell division
mitotic spindle assembly
microtubule depolymerization
cell cycle
mitotic nuclear division
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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