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Proteintech
KIF3A Polyclonal Antibody
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Product Details
13930-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KIF3A Fusion Protein Ag4954 (1-355 aa encoded by BC045542)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody specifically recognizes the endogenous KIF3A protein in mouse embryonic fibroblasts (MEFs) but not in KIF3A-/- lysate.
Immunogen sequence: MPINKSEKP ESCDNVKVVV RCRPLNEREK SMCYKQAVSV DEMRGTITVH KTDSSNEPPK TFTFDTVFGP ESKQLDVYNL TARPIIDSVL EGYNGTIFAY GQTGTGKTFT MEGVRAIPEL RGIIPNSFAH IFGHIAKAEG DTRFLVRVSY LGIYNEEVRD LLGKDQTQRL EVIERPDVGV YIKDLSAYVV NNADDMDRIM TLGHKNRSVG ATNMNEHSSR SHAIFTITIE CSEKGIDGNM HVRMGKLHLV DLAGSERQAK TGATGQRLKE ATKINLSLST LGNVISALVD GKSTHVPYRN SKLTRLLQDS LGGNSKTMMC ANIGPADYNY DETISTLRYA NRAKNIKNKA RINEDP (1-355 aa encoded by B C045542)
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport and membrane trafficking events including endocytosis and transcytosis. Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C. KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis. KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: kinesin family protein 3A; kinesin-II subunit; Kinesin-like protein KIF3A; Microtubule plus end-directed kinesin motor 3A; N-4 kinesin
Gene Aliases: FLA10; KIF3; KIF3A; Kifl; KLP-20; Kns3
UniProt ID: (Human) Q9Y496, (Mouse) P28741
Entrez Gene ID: (Human) 11127, (Mouse) 16568
retrograde vesicle-mediated transport, Golgi to ER
organelle organization
microtubule-based movement
antigen processing and presentation of exogenous peptide antigen via MHC class II
neurogenesis
cilium assembly
cilium morphogenesis
plus-end-directed vesicle transport along microtubule
in utero embryonic development
kidney development
heart looping
smoothened signaling pathway
determination of left/right symmetry
heart development
epidermis development
anterior/posterior pattern specification
dorsal/ventral pattern formation
dentate gyrus development
dorsal/ventral neural tube patterning
neural tube development
cell projection organization
nonmotile primary cilium assembly
epidermal stem cell homeostasis
positive regulation of receptor-mediated endocytosis
positive regulation of epithelial cell proliferation
inner ear receptor stereocilium organization
neural precursor cell proliferation
motile primary cilium assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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