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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:1,000-1:5,000 | View 4 publications 4 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
- | View 3 publications 3 publications |
Immunoprecipitation (IP) |
0.5-4.0 µg | View 1 publication 1 publication |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KIF5B Fusion Protein Ag16250 (662-782 aa encoded by BC126279) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.53 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: ESVDALSEE LVQLRAQEKV HEMEKEHLNK VQTANEVKQA VEQQIQSHRE THQKQISSLR DEVEAKAKLI TDLQDQNQKM MLEQERLRVE HEKLKATDQE KSRKLHELTV MQDRREQARQ DL (662-782 aa encoded by BC126279)
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Conventional kinesin heavy chain; epididymis secretory protein Li 61; kif5b {ECO:0000312|EMBL:ABC25059.1}; kinesin 1 (110-120kD); kinesin heavy chain; kinesin heavy chain member 5B, ubiquitous; Kinesin-1 heavy chain; U-KHC; Ubiquitous kinesin heavy chain; UKHC
Gene Aliases: AL022807; HEL-S-61; Khc; Khcs; KIF5B; KINH; KNS; KNS1; UKHC
UniProt ID: (Human) P33176, (Mouse) Q61768, (Rat) Q2PQA9
Entrez Gene ID: (Human) 3799, (Mouse) 16573, (Rat) 117550
Molecular Function:
microtubule binding motor protein
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