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Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Conventional kinesin heavy chain; epididymis secretory protein Li 61; kinesin 1 (110-120kD); kinesin heavy chain; Kinesin-1 heavy chain; U-KHC; Ubiquitous kinesin heavy chain; UKHC
Gene Aliases: HEL-S-61; KIF5B; KINH; KNS; KNS1; UKHC
UniProt ID: (Human) P33176
Entrez Gene ID: (Human) 3799
Molecular Function:
cytoskeletal protein
microtubule binding motor protein
microtubule family cytoskeletal protein
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