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Proteintech
KIF5B Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-21632
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KIF5B fusion protein Ag16250
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: ESVDALSEEL VQLRAQEKVH EMEKEHLNKV QTANEVKQAV EQQIQSHRET HQKQISSLRD EVEAKAKLIT DLQDQNQKMM LEQERLRVEH EKLKATDQEK SRKLHELTVM QDRREQARQD L
Target Information
Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Conventional kinesin heavy chain; epididymis secretory protein Li 61; kif5b {ECO:0000312|EMBL:ABC25059.1}; kinesin 1 (110-120kD); kinesin heavy chain; kinesin heavy chain member 5B, ubiquitous; Kinesin-1 heavy chain; U-KHC; Ubiquitous kinesin heavy chain; UKHC; unnamed protein product
Gene Aliases: AL022807; HEL-S-61; Khc; Khcs; KIF5B; KINH; KNS; KNS1; UKHC
UniProt ID: (Human) P33176, (Mouse) Q61768, (Rat) Q2PQA9
Entrez Gene ID: (Human) 3799, (Mouse) 16573, (Rat) 117550
microtubule-based movement
cytoplasm organization
axon guidance
positive regulation of synaptic transmission, GABAergic
lysosome localization
stress granule disassembly
natural killer cell mediated cytotoxicity
regulation of membrane potential
positive regulation of potassium ion transport
vesicle transport along microtubule
mitochondrion transport along microtubule
synaptic vesicle transport
centrosome localization
cellular response to interferon-gamma
plus-end-directed vesicle transport along microtubule
anterograde dendritic transport of neurotransmitter receptor complex
regulation of modification of synapse structure, modulating synaptic transmission
anterograde axonal protein transport
mitocytosis
positive regulation of protein localization to plasma membrane
anterograde neuronal dense core vesicle transport
retrograde neuronal dense core vesicle transport
mitochondrial transport
microtubule-based process
protein localization
metabolic process
positive regulation of establishment of protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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