Proteintech

KIFC1 Polyclonal Antibody

KIFC1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

KIFC1 Antibody (20790-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using KIFC1 antibody 20790-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

KIFC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

20790-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Peptide Array (Array)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KIFC1 Fusion Protein Ag14492 (382-725 aa encoded by BC000712)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody was raised against the C-terminal region of human KIFC1 protein, and recognizes 55-70 kDa of endogenous KIFC1 protein in multiple tissue lysates.^M
^M
Immunogen sequence: GLLLFPSGP GGPSDPPTRL SLSRSDERRG TLSGAPAPPP RHDFSFDRVF PPGSGQDEVF EEIAMLVQSA LDGYPVCIFA YGQTGSGKTF TMEGGPGGDP QLEGLIPRAL RHLFSVAQEL SGQGWTYSFV ASYVEIYNET VRDLLATGTR KGQGGECEIR RAGPGSEELT VTNARYVPVS CEKEVDALLH LARQNRAVAR TAQNERSSRS HSVFQLQISG EHSSRGLQCG APLSLVDLAG SERLDPGLAL GPGERERLRE TQAINSSLST LGLVIMALSN KESHVPYRNS KLTYLLQNSL GGSAKMLMFV NISPLEENVS ESLNSLRFAS KVNQCVIGTA QANRK (382-725 aa encoded by BC000712)

Target Information

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mechanism of spindle pole organization and instability in human oocytes.

Science (New York, N.Y.)

So C,Menelaou K,Uraji J,Harasimov K,Steyer AM,Seres KB,Bucevičius J,Lukinavičius G,Möbius W,Sibold C,Tandler-Schneider A,Eckel H,Moltrecht R,Blayney M,Elder K,Schuh M

Fri Feb 11 00:00:00 UTC 2022

Mechanism of spindle pole organization and instability in human oocytes.

Science (New York, N.Y.)

So C,Menelaou K,Uraji J,Harasimov K,Steyer AM,Seres KB,Bucevičius J,Lukinavičius G,Möbius W,Sibold C,Tandler-Schneider A,Eckel H,Moltrecht R,Blayney M,Elder K,Schuh M

Fri Feb 11 00:00:00 UTC 2022

Mechanism of spindle pole organization and instability in human oocytes.

Science (New York, N.Y.)

So C,Menelaou K,Uraji J,Harasimov K,Steyer AM,Seres KB,Bucevičius J,Lukinavičius G,Möbius W,Sibold C,Tandler-Schneider A,Eckel H,Moltrecht R,Blayney M,Elder K,Schuh M

Fri Feb 11 00:00:00 UTC 2022

KIFC1 Regulates the Trajectory of Neuronal Migration.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Muralidharan H,Guha S,Madugula K,Patil A,Bennison SA,Sun X,Toyo-Oka K,Baas PW

Wed Mar 16 00:00:00 UTC 2022

Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons.

Frontiers in molecular neuroscience

Sabui A,Biswas M,Somvanshi PR,Kandagiri P,Gorla M,Mohammed F,Tammineni P

Wed Oct 19 00:00:00 UTC 2022

Prognostic Value and Immunological Role of KIFC1 in Hepatocellular Carcinoma.

Frontiers in molecular biosciences

Li D,Yu T,Han J,Xu X,Wu J,Song W,Liu G,Zhu H,Zeng Z

Fri Feb 04 00:00:00 UTC 2022

Mitotic Motor KIFC1 Is an Organizer of Microtubules in the Axon.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Muralidharan H,Baas PW

Wed May 15 00:00:00 UTC 2019

Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation.

Cellular and molecular life sciences : CMLS

Canato S,Santos JD,Carvalho AS,Aloria K,Amaral MD,Matthiesen R,Falcao AO,Farinha CM

Sat Dec 01 00:00:00 UTC 2018

Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation.

Cellular and molecular life sciences : CMLS

Canato S,Santos JD,Carvalho AS,Aloria K,Amaral MD,Matthiesen R,Falcao AO,Farinha CM

Sat Dec 01 00:00:00 UTC 2018

Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lee SH,Joo K,Jung EJ,Hong H,Seo J,Kim J

Thu Feb 01 00:00:00 UTC 2018

Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lee SH,Joo K,Jung EJ,Hong H,Seo J,Kim J

Thu Feb 01 00:00:00 UTC 2018

Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects.

Genes

Zhi E,Li P,Chen H,Xu P,Zhu X,Zhu Z,He Z,Li Z

Tue Sep 27 00:00:00 UTC 2016

Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects.

Genes

Zhi E,Li P,Chen H,Xu P,Zhu X,Zhu Z,He Z,Li Z

Tue Sep 27 00:00:00 UTC 2016

Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects.

Genes

Zhi E,Li P,Chen H,Xu P,Zhu X,Zhu Z,He Z,Li Z

Tue Sep 27 00:00:00 UTC 2016

Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects.

Genes

Zhi E,Li P,Chen H,Xu P,Zhu X,Zhu Z,He Z,Li Z

Tue Sep 27 00:00:00 UTC 2016

Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds.

Developmental cell

Kwon M,Bagonis M,Danuser G,Pellman D

Mon Aug 10 00:00:00 UTC 2015

Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds.

Developmental cell

Kwon M,Bagonis M,Danuser G,Pellman D

Mon Aug 10 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: kifc1; kifc1 {ECO:0000312|EMBL:AAH83827.1, ECO:0000312|RGD:1359118}; kinesin family c-terminal 5A; kinesin motor protein KIFC4; kinesin-like 2; kinesin-like 2a; Kinesin-like protein 2; Kinesin-like protein KIFC1; Kinesin-related protein 1; Kinesin-related protein HSET; kinesin-related protein KIFC5A; kinesin-related protein KRP1

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Gene Aliases: HSET; 100042970; Gm4137; KIFC1; Kifc4; Kifc5a; Kifc5b; KNSL2; Knsl2a; Krp1; Tctex-7; Tctex-7A; Tctex7; Tctex7a

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UniProt ID: (Human) Q9BW19, (Mouse) Q9QWT9, (Rat) Q5XI63

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Entrez Gene ID: (Human) 3833, (Mouse) 100502766, (Rat) 294286

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Function(s)

microtubule motor activity ATP binding microtubule binding ATPase activity protein binding ATP-dependent microtubule motor activity, minus-end-directed membrane trafficking regulatory protein microtubule binding motor protein

Process(es)

mitotic sister chromatid segregation microtubule-based movement mitotic metaphase plate congression spermatogenesis cell division mitotic spindle assembly negative regulation of centrosome duplication vesicle transport along microtubule spindle assembly minus-end-directed vesicle transport along microtubule metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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KIFC1 Polyclonal Antibody

KIFC1 Antibody (20790-1-AP) in ICC/IF

Product Details

20790-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Peptide Array (Array)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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