Recommended positive controls: 293T, A431, H1299, HeLa, Molt-4, Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD158 antigen-like family member K; CD158k; Killer cell immunoglobulin-like receptor 3DL2; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2; killer Ig receptor; killer-cell immunoglobulin-like receptor; killer-cell immunoglobulin-like receptor 3DL2; KIR antigen 3DL2; LOC727787; MHC class I NK cell receptor; natural killer cell receptor; Natural killer-associated transcript 4; NKAT-4; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clone CL-5; p70 NK receptor CL-5
Gene Aliases: 3DL2; CD158K; KIR-3DL2; KIR3DL2; NKAT-4; NKAT4; NKAT4B; p140
UniProt ID: (Human) P43630
Entrez Gene ID: (Human) 3812