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Product Details
PA5-106920
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KISS1(Accession Q15726), corresponding to amino acid residues A88-G138.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2854584
Product Specific Information
Antibody detects endogenous levels of total KISS1.
Target Information
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH neurons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 0610012C01Rik; Kiss1 metastasis-suppressor; Kiss1 variant E1a-E2b-E3; Kiss1 variant E1b-E2a-E3; Kiss1 variant E1b-E2b-E3; Kisspeptin-1; malignant melanoma metastasis-suppressor; Metastasis-suppressor KiSS-1; metastin; MLL septin-like fusion; prepro-kisspeptin
Gene Aliases: Eseptin; HH13; KiSS-1; KISS1; kisspeptin; metastatin; PP5098
UniProt ID: (Human) Q15726, (Rat) Q7TSB7, (Mouse) Q6Y4S4
Entrez Gene ID: (Human) 3814, (Rat) 289023, (Mouse) 280287
cytoskeleton organization
negative regulation of cell proliferation
positive regulation of luteinizing hormone secretion
positive regulation of MAPK cascade
positive regulation of synaptic transmission
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
generation of ovulation cycle rhythm
positive regulation of growth hormone secretion
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
negative regulation of cell migration
positive regulation of stress-activated MAPK cascade
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