KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.
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Protein Aliases: Beta-klotho; betaKlotho; BKL; klotho beta like; Klotho beta-like protein; MGC142213
Gene Aliases: BKL; KLB
UniProt ID: (Human) Q86Z14
Entrez Gene ID: (Human) 152831
Molecular Function: glycosidase