Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).
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Protein Aliases: EKLF; endothelial Kruppel-like zinc finger protein; Epithelial zinc finger protein EZF; Erythroid krueppel-like transcription factor; erythroid Kruppel-like factor; erythroid transcription factor; erythroid-specific transcription factor EKLF; gut Kruppel-like factor; Gut-enriched krueppel-like factor; Krueppel-like factor 1; Krueppel-like factor 2; Krueppel-like factor 4; Kruppel-like factor 1 (erythroid); Kruppel-like factor 2 (lung); Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF); Kruppel-like factor 4 (gut); Kruppel-like factor LKLF; Lung krueppel-like factor; lung Kruppel-like factor; lung Kruppel-like zinc finger transcription factor; monoclonal antibody A3D8; neonatal anemia; truncated EKLF; truncated erythroid Kruppel-like factor 1
Gene Aliases: CDAN4; EKLF; EZF; GKLF; HBFQTL6; INLU; KLF1; KLF2; KLF4; LKLF; Nan; Zie