|Tested species reactivity||Human, Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 254-283 amino acids from the C-terminal region of human KLF14|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 1 publications below|
This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.
PA5-23784 was used in western blot to study how KLF14 regulates lipid metabolism and affects atherosclerosis
|Guo Y,Fan Y,Zhang J,Lomberk GA,Zhou Z,Sun L,Mathison AJ,Garcia-Barrio MT,Zhang J,Zeng L,Li L,Pennathur S,Willer CJ,Rader DJ,Urrutia R,Chen YE||The Journal of clinical investigation (125:3819)||2015|